GABRB1 - Gamma-aminobutyric acid receptor subunit beta-1 - human protein (Function)
 
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GABRB1 »  Gamma-aminobutyric acid receptor subunit beta-1
 
Protein also known as:  GABA(A) receptor subunit beta-1.
Gene name:  GABRB1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 41 2
GENE REF ISO

Function

 show evidences
Overview 
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.  
  • CuratedUniProtKB
GO molecular function 
Chloride channel activitydefinition[GO:0005254]  
  • IEAUniProtKB KW
Extracellular ligand-gated ion channel activitydefinition[GO:0005230] silver  
  • IEAInterPro 2 GO
GABA-A receptor activitydefinition[GO:0004890]  
  • ISSOrtholog Curator
Ligand-gated ion channel activitydefinition[GO:0015276]  
  • ISSOrtholog Curator
GO biological process 
Cellular response to histaminedefinition[GO:0071420]  
  • ISSOrtholog Curator
Chloride transmembrane transportdefinition[GO:1902476]  
  • IEAUniProtKB KW
Ion transportdefinition[GO:0006811]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+2560  
Neuroactive ligand-receptor interaction  hsa04080+2560  
According to Reactome, this protein belongs to the following pathways:
GABA A receptor activation  REACT_24987  
Ligand-gated ion channel transport  REACT_25387  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GABRB1
GenomeRNAi: 2560
PRO: PR:P18505
Chemistry
GuidetoPHARMACOLOGY: 410