GABRB1 - Gamma-aminobutyric acid receptor subunit beta-1 - human protein (Function)
 
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GABRB1 »  Gamma-aminobutyric acid receptor subunit beta-1
 
Protein also known as:  GABA(A) receptor subunit beta-1.
Gene name:  GABRB1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).  
1
  • UniProtKB
GO molecular function 
Chloride channel activitydefinition[GO:0005254]  
1
  • UniProtKB KW
Extracellular ligand-gated ion channel activitydefinition[GO:0005230] silver  
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  • InterPro 2 GO
GABA-A receptor activitydefinition[GO:0004890]  
1
  • Ortholog Curator
Ligand-gated ion channel activitydefinition[GO:0015276]  
1
  • Ortholog Curator
GO biological process 
Cellular response to histaminedefinition[GO:0071420]  
1
  • Ortholog Curator
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • UniProtKB KW
Ion transportdefinition[GO:0006811]  
1
  • Ortholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Transportdefinition[GO:0006810]  
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  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+2560  
Neuroactive ligand-receptor interaction  hsa04080+2560  
According to Reactome, this protein belongs to the following pathways:
GABA A receptor activation  REACT_24987  
Ligand-gated ion channel transport  REACT_25387  
Orphan transporters  REACT_268444  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GABRB1
GenomeRNAi: 2560
PRO: PR:P18505
Chemistry
GuidetoPHARMACOLOGY: 410