GABRB1 - Gamma-aminobutyric acid receptor subunit beta-1 - human protein (Function)
 
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GABRB1 »  Gamma-aminobutyric acid receptor subunit beta-1
 
Protein also known as:  GABA(A) receptor subunit beta-1.
Gene name:  GABRB1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).  
1
  • UniProtKB
GO molecular function 
Contributes to chloride channel activitydefinition[GO:0005254]  
1
  • RefGenome
Contributes to extracellular ligand-gated ion channel activitydefinition[GO:0005230]  
1
  • RefGenome
GABA receptor bindingdefinition[GO:0050811] silver  
1
  • Ortholog Compara
GABA-A receptor activitydefinition[GO:0004890]  
1
  • Ortholog Curator
Ligand-gated ion channel activitydefinition[GO:0015276]  
1
  • Ortholog Curator
GO biological process 
Cellular response to histaminedefinition[GO:0071420]  
1
  • Ortholog Curator
Central nervous system neuron developmentdefinition[GO:0021954] silver  
1
  • Ortholog Compara
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • RefGenome
Ion transportdefinition[GO:0006811]  
1
  • Ortholog Curator
Neurological system processdefinition[GO:0050877]  
1
  • RefGenome
Ovulation cycledefinition[GO:0042698] silver  
1
  • Ortholog Compara
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • RefGenome
Response to progesteronedefinition[GO:0032570] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Synaptic transmissiondefinition[GO:0007268]  
1
  • RefGenome
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+2560  
Neuroactive ligand-receptor interaction  hsa04080+2560  
According to Reactome, this protein belongs to the following pathways:
GABA A receptor activation  R-HSA-977441  
Ligand-gated ion channel transport  R-HSA-975298  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GABRB1
GenomeRNAi: 2560
PRO: PR:P18505
Chemistry
GuidetoPHARMACOLOGY: 410