GABRG2 - Gamma-aminobutyric acid receptor subunit gamma-2 - human protein (Function)
 
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GABRG2 »  Gamma-aminobutyric acid receptor subunit gamma-2
 
Protein also known as:  GABA(A) receptor subunit gamma-2.
Gene name:  GABRG2
Entry whose protein(s) existence is based on evidence at protein level
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1 90 3
GENE REF ISO

Function

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Overview 
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.  
2
  • UniProtKB
GO molecular function 
Benzodiazepine receptor activitydefinition[GO:0008503]  
1
  • PINC
Chloride channel activitydefinition[GO:0005254]  
1
  • Ortholog Curator
Extracellular ligand-gated ion channel activitydefinition[GO:0005230] silver  
1
  • InterPro 2 GO
GABA-A receptor activitydefinition[GO:0004890]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Adult behaviordefinition[GO:0030534] silver  
1
  • Ortholog Compara
Cellular response to histaminedefinition[GO:0071420]  
1
  • Ortholog Curator
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • Ortholog Curator
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
1
  • Ortholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
1
  • Ortholog Compara
Synaptic transmission, GABAergicdefinition[GO:0051932]  
1
  • Ortholog Curator
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+2566  
Neuroactive ligand-receptor interaction  hsa04080+2566  
According to Reactome, this protein belongs to the following pathways:
GABA A receptor activation  REACT_24987  
Ligand-gated ion channel transport  REACT_25387  
Orphan transporters  REACT_268444  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GABRG2
GenomeRNAi: 2566
PRO: PR:P18507
Chemistry
GuidetoPHARMACOLOGY: 414