GABRG2 - Gamma-aminobutyric acid receptor subunit gamma-2 - human protein (Sequence)
 
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GABRG2 »  Gamma-aminobutyric acid receptor subunit gamma-2
 
Protein also known as:  GABA(A) receptor subunit gamma-2.
Gene name:  GABRG2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 81 3
GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   467 aaMass: 54162 Da,  pI: 8.72
MSSPNIWSTG SSVYSTPVFS QKMTVWILLL LSLYPGFTSQ KSDDDYEDYA SNKTWVLTPK VPEGDVTVIL NNLLEGYDNK LRPDIGVKPT LIHTDMYVNS IGPVNAINME YTIDIFFAQT WYDRRLKFNS TIKVLRLNSN MVGKIWIPDT FFRNSKKADA HWITTPNRML RIWNDGRVLY TLRLTIDAEC QLQLHNFPMD EHSCPLEFSS YGYPREEIVY QWKRSSVEVG DTRSWRLYQF SFVGLRNTTE VVKTTSGDYV VMSVYFDLSR RMGYFTIQTY IPCTLIVVLS WVSFWINKDA VPARTSLGIT TVLTMTTLST IARKSLPKVS YVTAMDLFVS VCFIFVFSAL VEYGTLHYFV SNRKPSKDKD KKKKNPAPTI DIRPRSATIQ MNNATHLQER DEEYGYECLD GKDCASFFCC FEDCRTGAWR HGRIHIRIAK MDSYARIFFP TAFCLFNLVY WVSYLYL

Sequence

 show evidences
PTM 
Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability (By similarity).  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Domain 
Signal  definition   [KW-0732]
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Disulfide bond  definition   [KW-1015]
Glycoprotein  definition   [KW-0325]
Lipoprotein  definition   [KW-0449]
Palmitate  definition   [KW-0564]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 2.70.170.10
InterPro: IPR006202 [ Neur chan lig-bd ]
InterPro: IPR005437 [ GABBAg rcpt ]
InterPro: IPR018000 [ Neurotransmitter ion chnl CS ]
InterPro: IPR005439 [ GABBAg2 rcpt ]
InterPro: IPR006028 [ GABAA/Glycine rcpt ]
InterPro: IPR006201 [ Neur channel ]
InterPro: IPR006029 [ Neurotrans-gated channel TM ]
PANTHER: PTHR18945 [ PTHR18945 ]
Pfam: PF02932 [ Neur chan memb ]
Pfam: PF02931 [ Neur chan LBD ]
PRINTS: PR01620 [ GABAARGAMMA ]
PRINTS: PR01622 [ GABAARGAMMA2 ]
PRINTS: PR00252 [ NRIONCHANNEL ]
PRINTS: PR00253 [ GABAARECEPTR ]
PROSITE: PS00236 [ NEUROTR ION CHANNEL ]
SUPFAM: SSF63712 [ SSF63712 ]
SUPFAM: SSF90112 [ SSF90112 ]
TIGRFAMs: TIGR00860 [ LIC ]
Genome annotation databases
Ensembl: Transcript: ENST00000361925;  Protein: ENSP00000354651;  Gene: ENSG00000113327.
Ensembl: Transcript: ENST00000356592;  Protein: ENSP00000349000;  Gene: ENSG00000113327.
Ensembl: Transcript: ENST00000414552;  Protein: ENSP00000410732;  Gene: ENSG00000113327.
Ensembl: Transcript: ENST00000522990;  Protein: ENSP00000430732;  Gene: ENSG00000113327.
Ensembl: Transcript: ENST00000523372;  Protein: ENSP00000430124;  Gene: ENSG00000113327.
Ensembl: Transcript: ENST00000522053;  Protein: ENSP00000430182;  Gene: ENSG00000113327.
Ensembl: Transcript: ENST00000393933;  Protein: ENSP00000377510;  Gene: ENSG00000113327.
KEGG: hsa:2566
UCSC: uc003lyz.4
UCSC: uc003lyy.4
Organism-specific databases
MGI: MGI:95623 [ Gabrg2 ]
PTM databases
PhosphoSite: P18507
Phylogenomic databases
eggNOG: NOG238757
HOGENOM: HOG000231337
HOVERGEN: HBG051707
KO: K05186
OMA: PGFTSQK
OrthoDB: EOG7JX342
PhylomeDB: P18507
Sequence databases
CCDS: CCDS47333.1 [ P18507-3 ]
CCDS: CCDS4358.1 [ P18507-1 ]
CCDS: CCDS4359.1 [ P18507-2 ]
EMBL: Genomic DNA:  AF165124 . Translation:  AAD50273.1 .
EMBL: Genomic DNA:  AC091926 . No translation available.
EMBL: mRNA:  X15376 . Translation:  CAA33437.1 .
EMBL: mRNA:  BC059389 . Translation:  AAH59389.1 .
EMBL: mRNA:  BC069348 . Translation:  AAH69348.1 .
EMBL: Genomic DNA:  AC008611 . No translation available.
EMBL: Genomic DNA:  AC091984 . No translation available.
EMBL: mRNA:  BC074795 . Translation:  AAH74795.1 .
IPI: IPI00419200
IPI: IPI00000023
PIR: S03905
RefSeq: Protein:  NP_944494.1. Nucleotide sequence:  NM_198904.2.
RefSeq: Protein:  NP_944493.2. Nucleotide sequence:  NM_198903.2.
RefSeq: Protein:  NP_000807.2. Nucleotide sequence:  NM_000816.3.
UniProtKB: P18507