ADCYAP1 - Pituitary adenylate cyclase-activating polypeptide - human protein (Function)
 
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ADCYAP1 »  Pituitary adenylate cyclase-activating polypeptide  (PACAP)
 
Cleaved into:  PACAP-related peptide; Pituitary adenylate cyclase-activating polypeptide 27; Pituitary adenylate cyclase-activating polypeptide 38.
Gene name:  ADCYAP1
Family name: Glucagon
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 78 1
GENE REF ISO

Function

 show evidences
Overview 
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.  
3
  • UniProtKB
GO molecular function 
Neuropeptide hormone activitydefinition[GO:0005184]  
1
  • UniProtKB
Peptide hormone receptor bindingdefinition[GO:0051428]  
2
  • UniProtKB
Pituitary adenylate cyclase activating polypeptide activitydefinition[GO:0016521]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Receptor bindingdefinition[GO:0005102]  
1
  • BHF-UCL
Receptor signaling protein activitydefinition[GO:0005057] silver  
1
  • Ortholog Compara
GO biological process 
cAMP-mediated signalingdefinition[GO:0019933]  
1
  • UniProtKB
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Female pregnancydefinition[GO:0007565]  
1
  • PINC
Negative regulation of cell cycledefinition[GO:0045786] silver  
1
  • Ortholog Compara
Neuron projection developmentdefinition[GO:0031175]  
1
  • UniProtKB
Neuropeptide signaling pathwaydefinition[GO:0007218]  
1
  • UniProtKB
Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579]  
1
  • BHF-UCL
Positive regulation of chemokine (C-C motif) ligand 5 productiondefinition[GO:0071651] silver  
1
  • CACAO
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • UniProtKB
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • UniProtKB
Positive regulation of protein kinase activitydefinition[GO:0045860]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
1
  • UniProtKB
Regulation of protein localizationdefinition[GO:0032880]  
1
  • BHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (s) signalling events  R-HSA-418555  
Glucagon-type ligand receptors  R-HSA-420092  
NGF-independant TRKA activation  R-HSA-187024  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links