ADCYAP1 - Pituitary adenylate cyclase-activating polypeptide - human protein (Function)
 
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ADCYAP1 »  Pituitary adenylate cyclase-activating polypeptide  (PACAP)
 
Cleaved into:  PACAP-related peptide; Pituitary adenylate cyclase-activating polypeptide 27; Pituitary adenylate cyclase-activating polypeptide 38.
Gene name:  ADCYAP1
Family name: Glucagon
Entry whose protein(s) existence is based on evidence at protein level
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1 66 1
GENE REF ISO

Function

 show evidences
Overview 
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.  
2
  • CuratedUniProtKB
GO molecular function 
Neuropeptide hormone activitydefinition[GO:0005184]  
1
  • IDAUniProtKB
Peptide hormone receptor bindingdefinition[GO:0051428]  
2
  • IPIUniProtKB
Pituitary adenylate cyclase activating polypeptide activitydefinition[GO:0016521]  
1
  • IDABHF-UCL
Pituitary adenylate cyclase-activating polypeptide receptor bindingdefinition[GO:0031858] silver  
  • IEAOrtholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • IPIBHF-UCL
Receptor signaling protein activitydefinition[GO:0005057] silver  
  • IEAOrtholog Compara
GO biological process 
ATP metabolic processdefinition[GO:0046034] silver  
  • IEAOrtholog Compara
Behavioral fear responsedefinition[GO:0001662] silver  
  • IEAOrtholog Compara
cAMP-mediated signalingdefinition[GO:0019933]  
1
  • IMPUniProtKB
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cellular response to glucocorticoid stimulusdefinition[GO:0071385] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565]  
1
  • TASPINC
Histamine secretiondefinition[GO:0001821] silver  
  • IEAOrtholog Compara
Negative regulation of acute inflammatory response to antigenic stimulusdefinition[GO:0002865] silver  
  • IEAOrtholog Compara
Negative regulation of acute inflammatory response to non-antigenic stimulusdefinition[GO:0002878] silver  
  • IEAOrtholog Compara
Negative regulation of cell cycledefinition[GO:0045786] silver  
  • IEAOrtholog Compara
Negative regulation of glial cell proliferationdefinition[GO:0060253] silver  
  • IEAOrtholog Compara
Negative regulation of muscle cell apoptotic processdefinition[GO:0010656] silver  
  • IEAOrtholog Compara
Negative regulation of potassium ion transportdefinition[GO:0043267] silver  
  • IEAOrtholog Compara
Negative regulation of Rho GTPase activitydefinition[GO:0034259] silver  
  • IEAOrtholog Compara
Neuron projection developmentdefinition[GO:0031175]  
1
  • IDAUniProtKB
Neuropeptide signaling pathwaydefinition[GO:0007218]  
1
  • IDAUniProtKB
Ovarian follicle developmentdefinition[GO:0001541] silver  
  • IEAOrtholog Compara
Pituitary gland developmentdefinition[GO:0021983] silver  
  • IEAOrtholog Compara
Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579]  
1
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IDAUniProtKB
Positive regulation of growth hormone secretiondefinition[GO:0060124] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-6 productiondefinition[GO:0032755] silver  
  • IEAOrtholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
  • IEAOrtholog Compara
Positive regulation of protein kinase activitydefinition[GO:0045860]  
1
  • IDAUniProtKB
Positive regulation of Rap GTPase activitydefinition[GO:0032854]  
1
  • IDAUniProtKB
Positive regulation of somatostatin secretiondefinition[GO:0090274] silver  
  • IEAOrtholog Compara
Positive regulation of synaptic transmission, glutamatergicdefinition[GO:0051968] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Positive regulation of vasodilationdefinition[GO:0045909] silver  
  • IEAOrtholog Compara
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
1
  • IDAUniProtKB
Regulation of oligodendrocyte progenitor proliferationdefinition[GO:0070445] silver  
  • IEAOrtholog Compara
Regulation of postsynaptic membrane potentialdefinition[GO:0060078] silver  
  • IEAOrtholog Compara
Regulation of protein localizationdefinition[GO:0032880]  
1
  • IDABHF-UCL
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links