IL1RN - Interleukin-1 receptor antagonist protein - human protein (Function)
 
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IL1RN »  Interleukin-1 receptor antagonist protein  (IRAP)
 
Protein also known as:  IL1 inhibitor; International Nonproprietary Name Anakinra.
Gene name:  IL1RN
Entry whose protein(s) existence is based on evidence at protein level
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1 301 4
GENE REF ISO

Function

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Overview 
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.  
1
  • CuratedUniProtKB
GO molecular function 
Interleukin-1 receptor antagonist activitydefinition[GO:0005152]  
3
  • TASUniProtKB
  • IDABHF-UCL
Isoform  Iso 1   Interleukin-1 receptor bindingdefinition[GO:0005149]  
1
  • IDABHF-UCL
Interleukin-1 Type I receptor antagonist activitydefinition[GO:0045352]  
1
  • IDABHF-UCL
Interleukin-1 Type II receptor antagonist activitydefinition[GO:0045353]  
1
  • IDABHF-UCL
Interleukin-1, Type I receptor bindingdefinition[GO:0005150]  
1
  • IPIBHF-UCL
Interleukin-1, Type II receptor bindingdefinition[GO:0005151]  
1
  • IPIBHF-UCL
GO biological process 
Isoform  Iso 1   Acute-phase responsedefinition[GO:0006953]  
1
  • IDABHF-UCL
Carboxylic acid metabolic processdefinition[GO:0019752] silver  
  • IEAOrtholog Compara
Chronic inflammatory response to antigenic stimulusdefinition[GO:0002439] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Fever generationdefinition[GO:0001660] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • NASUniProtKB
Insulin secretiondefinition[GO:0030073] silver  
  • IEAOrtholog Compara
Lipid metabolic processdefinition[GO:0006629] silver  
  • IEAOrtholog Compara
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of cell migrationdefinition[GO:0030336] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Negative regulation of cytokine-mediated signaling pathwaydefinition[GO:0001960]  
1
  • IDAGOC
Negative regulation of glutamate secretiondefinition[GO:0014050] silver  
  • IEAOrtholog Compara
Negative regulation of heterotypic cell-cell adhesiondefinition[GO:0034115]  
1
  • IDABHF-UCL
Negative regulation of interleukin-1-mediated signaling pathwaydefinition[GO:2000660]  
2
  • IDABHF-UCL
Negative regulation of membrane potentialdefinition[GO:0045837] silver  
  • IEAOrtholog Compara
Positive regulation of JUN kinase activitydefinition[GO:0043507] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384]  
1
  • IDABHF-UCL
Response to interleukin-4definition[GO:0070670] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to organonitrogen compounddefinition[GO:0010243] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interleukin-1 signaling  REACT_22442  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links