ADRA2C - Alpha-2C adrenergic receptor - human protein (Function)
 
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Protein
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ADRA2C »  Alpha-2C adrenergic receptor
 
Gene name:  ADRA2C
Entry whose protein(s) existence is based on evidence at transcript level
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1 43 1
GENE REF ISO

Function

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Overview 
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.  
  • CuratedUniProtKB
GO molecular function 
Alpha-2A adrenergic receptor bindingdefinition[GO:0031694]  
1
  • IPIBHF-UCL
Alpha2-adrenergic receptor activitydefinition[GO:0004938]  
1
  • IDABHF-UCL
Epinephrine bindingdefinition[GO:0051379]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
GO biological process 
Activation of MAPK activity by adrenergic receptor signaling pathwaydefinition[GO:0071883]  
1
  • IDABHF-UCL
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • IDABHF-UCL
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwaydefinition[GO:0035625]  
1
  • IDABHF-UCL
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Negative regulation of epinephrine secretiondefinition[GO:0032811]  
1
  • NASBHF-UCL
Negative regulation of norepinephrine secretiondefinition[GO:0010700]  
2
  • TASBHF-UCL
Negative regulation of uterine smooth muscle contractiondefinition[GO:0070473] silver  
  • IEAOrtholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666]  
1
  • IDABHF-UCL
Positive regulation of vasoconstrictiondefinition[GO:0045907] silver  
  • IEAOrtholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+152  
According to Reactome, this protein belongs to the following pathways:
Adrenaline signalling through Alpha-2 adrenergic receptor  REACT_19180  
Adrenaline,noradrenaline inhibits insulin secretion  REACT_18339  
Adrenoceptors  REACT_16927  
G alpha (i) signalling events  REACT_19231  
G alpha (z) signalling events  REACT_19333  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Alpha-2C_adrenergic_receptor
GenomeRNAi: 152
PRO: PR:P18825
Chemistry
GuidetoPHARMACOLOGY: 27