ATF1 - Cyclic AMP-dependent transcription factor ATF-1 - human protein (Function)
 
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ATF1 »  Cyclic AMP-dependent transcription factor ATF-1  (cAMP-dependent transcription factor ATF-1)
 
Protein also known as:  Activating transcription factor 1.
Gene name:  ATF1
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
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1 73 2
GENE REF ISO

Function

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Overview 
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
1
  • Ortholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • NTNU_SB
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001228]  
1
  • NTNU_SB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • PINC
GO biological process 
Cellular protein complex assemblydefinition[GO:0043623] silver  
1
  • Ortholog Compara
Positive regulation of DNA replicationdefinition[GO:0045740] silver  
1
  • Ortholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • NTNU_SB
Response to cobalt iondefinition[GO:0032025] silver  
1
  • Ortholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
HTLV-I infection  hsa05166+466  
According to Reactome, this protein belongs to the following pathway:
CREB phosphorylation  REACT_12524  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATF1
GenomeRNAi: 466
PRO: PR:P18846