ATF3 - Cyclic AMP-dependent transcription factor ATF-3 - human protein (Function)
 
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ATF3 »  Cyclic AMP-dependent transcription factor ATF-3  (cAMP-dependent transcription factor ATF-3)
 
Protein also known as:  Activating transcription factor 3.
Gene name:  ATF3
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter.  
  • CuratedUniProtKB
Isoform  Iso 2   Activates transcription presumably by sequestering inhibitory cofactors away from the promoters.  
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDANTNU_SB
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001228]  
  • ICGO curators
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
Transcription corepressor activitydefinition[GO:0003714]  
1
  • TASPINC
GO biological process 
Gluconeogenesisdefinition[GO:0006094] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDANTNU_SB
Skeletal muscle cell differentiationdefinition[GO:0035914] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
HTLV-I infection  hsa05166+467  
According to Reactome, this protein belongs to the following pathway:
ATF4 activates genes  REACT_18355  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATF3
GenomeRNAi: 467
PRO: PR:P18847