ATF4 - Cyclic AMP-dependent transcription factor ATF-4 - human protein (Function)
 
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ATF4 »  Cyclic AMP-dependent transcription factor ATF-4  (cAMP-dependent transcription factor ATF-4)
 
Protein also known as:  Tax-responsive enhancer element-binding protein 67 (TaxREB67).
Gene name:  ATF4
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
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1 157 1
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed26086088).  
5
  • UniProtKB
GO molecular function 
Core promoter sequence-specific DNA bindingdefinition[GO:0001046]  
1
  • Ortholog Curator
DNA bindingdefinition[GO:0003677]  
3
  • UniProtKB
  • Ortholog Curator
Leucine zipper domain bindingdefinition[GO:0043522]  
1
  • ParkinsonsUK-UCL
Protein bindingdefinition[GO:0005515]  
16
  • IntAct
  • UniProtKB
  • HGNC
Protein C-terminus bindingdefinition[GO:0008022] silver  
1
  • Ortholog Compara
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • ParkinsonsUK-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • RefGenome
RNA polymerase II transcription factor activity, sequence-specific DNA bindingdefinition[GO:0000981]  
3
  • ParkinsonsUK-UCL
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • ParkinsonsUK-UCL
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • ParkinsonsUK-UCL
Transcription factor activity, RNA polymerase II transcription factor bindingdefinition[GO:0001076]  
1
  • ParkinsonsUK-UCL
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
2
  • UniProtKB
  • Ortholog Curator
Contributes to transcription regulatory region DNA bindingdefinition[GO:0044212]  
3
  • ParkinsonsUK-UCL
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001077] silver  
1
  • Ortholog Compara
GO biological process 
Cellular amino acid metabolic processdefinition[GO:0006520]  
1
  • UniProtKB
Cellular response to amino acid starvationdefinition[GO:0034198]  
1
  • Ortholog Curator
Cellular response to glucose starvationdefinition[GO:0042149]  
1
  • ParkinsonsUK-UCL
Cellular response to UVdefinition[GO:0034644]  
1
  • Ortholog Curator
Circadian regulation of gene expressiondefinition[GO:0032922]  
1
  • Ortholog Curator
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
1
  • Ortholog Compara
Gluconeogenesisdefinition[GO:0006094]  
1
  • Ortholog Curator
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
1
  • Ortholog Curator
mRNA transcription from RNA polymerase II promoterdefinition[GO:0042789]  
1
  • Ortholog Curator
Negative regulation of oxidative stress-induced neuron deathdefinition[GO:1903204]  
1
  • ParkinsonsUK-UCL
Negative regulation of potassium ion transportdefinition[GO:0043267] silver  
1
  • Ortholog Compara
Negative regulation of translational initiation in response to stressdefinition[GO:0032057]  
1
  • Ortholog Curator
PERK-mediated unfolded protein responsedefinition[GO:0036499]  
2
  • ParkinsonsUK-UCL
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • ParkinsonsUK-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • ParkinsonsUK-UCL
Positive regulation of neuron apoptotic processdefinition[GO:0043525]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase I promoterdefinition[GO:0045943]  
1
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
5
  • ParkinsonsUK-UCL
  • UniProtKB
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substancedefinition[GO:0061395]  
1
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressdefinition[GO:1990440]  
2
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stressdefinition[GO:0036091]  
2
  • ParkinsonsUK-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
5
  • UniProtKB
  • Ortholog Curator
Positive regulation of vascular endothelial growth factor productiondefinition[GO:0010575]  
1
  • ParkinsonsUK-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • Ortholog Curator
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
2
  • ParkinsonsUK-UCL
  • BHF-UCL
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+468  
Dopaminergic synapse  hsa04728+468  
GnRH signaling pathway  hsa04912+468  
HTLV-I infection  hsa05166+468  
Long-term potentiation  hsa04720+468  
MAPK signaling pathway  hsa04010+468  
Neurotrophin signaling pathway  hsa04722+468  
Prostate cancer  hsa05215+468  
Protein processing in endoplasmic reticulum  hsa04141+468  
According to Reactome, this protein belongs to the following pathways:
ATF4 activates genes  R-HSA-380994  
ATF6-alpha activates chaperone genes  R-HSA-381183  
PERK regulates gene expression  R-HSA-381042  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATF4
GenomeRNAi: 468
PRO: PR:P18848