ATF4 - Cyclic AMP-dependent transcription factor ATF-4 - human protein (Function)
 
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ATF4 »  Cyclic AMP-dependent transcription factor ATF-4  (cAMP-dependent transcription factor ATF-4)
 
Protein also known as:  Tax-responsive enhancer element-binding protein 67 (TaxREB67).
Gene name:  ATF4
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 136 1
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.  
4
  • UniProtKB
GO molecular function 
Core promoter sequence-specific DNA bindingdefinition[GO:0001046]  
1
  • Ortholog Curator
DNA bindingdefinition[GO:0003677]  
3
  • UniProtKB
  • Ortholog Curator
Leucine zipper domain bindingdefinition[GO:0043522]  
1
  • ParkinsonsUK-UCL
Protein bindingdefinition[GO:0005515]  
14
  • IntAct
  • UniProtKB
  • HGNC
Protein C-terminus bindingdefinition[GO:0008022] silver  
1
  • Ortholog Compara
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • ParkinsonsUK-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • ParkinsonsUK-UCL
RNA polymerase II transcription factor binding transcription factor activitydefinition[GO:0001076]  
1
  • ParkinsonsUK-UCL
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • ParkinsonsUK-UCL
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
3
  • ParkinsonsUK-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • UniProtKB
  • Ortholog Curator
Contributes to transcription regulatory region DNA bindingdefinition[GO:0044212]  
3
  • ParkinsonsUK-UCL
GO biological process 
Cellular amino acid metabolic processdefinition[GO:0006520]  
1
  • UniProtKB
Cellular response to glucose starvationdefinition[GO:0042149]  
1
  • ParkinsonsUK-UCL
Circadian regulation of gene expressiondefinition[GO:0032922]  
1
  • Ortholog Curator
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
1
  • Ortholog Compara
Gluconeogenesisdefinition[GO:0006094]  
1
  • Ortholog Curator
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
1
  • Ortholog Curator
Negative regulation of oxidative stress-induced neuron deathdefinition[GO:1903204]  
1
  • ParkinsonsUK-UCL
Negative regulation of potassium ion transportdefinition[GO:0043267] silver  
1
  • Ortholog Compara
PERK-mediated unfolded protein responsedefinition[GO:0036499]  
2
  • ParkinsonsUK-UCL
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • ParkinsonsUK-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • ParkinsonsUK-UCL
Positive regulation of neuron apoptotic processdefinition[GO:0043525]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase I promoterdefinition[GO:0045943]  
1
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
5
  • ParkinsonsUK-UCL
  • UniProtKB
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substancedefinition[GO:0061395]  
1
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressdefinition[GO:1990440]  
2
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stressdefinition[GO:0036091]  
2
  • ParkinsonsUK-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
5
  • UniProtKB
  • Ortholog Curator
Positive regulation of vascular endothelial growth factor productiondefinition[GO:0010575]  
1
  • ParkinsonsUK-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • Ortholog Curator
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
2
  • ParkinsonsUK-UCL
  • BHF-UCL
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+468  
Dopaminergic synapse  hsa04728+468  
GnRH signaling pathway  hsa04912+468  
HTLV-I infection  hsa05166+468  
Long-term potentiation  hsa04720+468  
MAPK signaling pathway  hsa04010+468  
Neurotrophin signaling pathway  hsa04722+468  
Prostate cancer  hsa05215+468  
Protein processing in endoplasmic reticulum  hsa04141+468  
According to Reactome, this protein belongs to the following pathways:
ATF4 activates genes  REACT_18355  
ATF6-alpha activates chaperone genes  REACT_18423  
PERK regulates gene expression  REACT_18277  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATF4
GenomeRNAi: 468
PRO: PR:P18848