ATF4 - Cyclic AMP-dependent transcription factor ATF-4 - human protein (Function)
 
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ATF4 »  Cyclic AMP-dependent transcription factor ATF-4  (cAMP-dependent transcription factor ATF-4)
 
Protein also known as:  Tax-responsive enhancer element-binding protein 67 (TaxREB67).
Gene name:  ATF4
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4.  
3
  • CuratedUniProtKB
GO molecular function 
Core promoter sequence-specific DNA bindingdefinition[GO:0001046]  
  • ISSOrtholog Curator
DNA bindingdefinition[GO:0003677]  
2
  • IDAUniProtKB
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
GO biological process 
Cellular amino acid metabolic processdefinition[GO:0006520]  
1
  • TASUniProtKB
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
  • IEAOrtholog Compara
Gluconeogenesisdefinition[GO:0006094]  
  • ISSOrtholog Curator
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
  • ISSOrtholog Curator
Negative regulation of potassium ion transportdefinition[GO:0043267] silver  
  • IEAOrtholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
4
  • IDAUniProtKB
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • ISSOrtholog Curator
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • IDABHF-UCL
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+468  
Dopaminergic synapse  hsa04728+468  
GnRH signaling pathway  hsa04912+468  
HTLV-I infection  hsa05166+468  
Long-term potentiation  hsa04720+468  
MAPK signaling pathway  hsa04010+468  
Neurotrophin signaling pathway  hsa04722+468  
Prostate cancer  hsa05215+468  
Protein processing in endoplasmic reticulum  hsa04141+468  
According to Reactome, this protein belongs to the following pathways:
ATF4 activates genes  REACT_18355  
ATF6-alpha activates chaperone genes  REACT_18423  
PERK regulates gene expression  REACT_18277  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATF4
GenomeRNAi: 468
PRO: PR:P18848