ATF6 - Cyclic AMP-dependent transcription factor ATF-6 alpha - human protein (Function)
 
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ATF6 »  Cyclic AMP-dependent transcription factor ATF-6 alpha  (cAMP-dependent transcription factor ATF-6 alpha)
 
Protein also known as:  Activating transcription factor 6 alpha (ATF6-alpha). Cleaved into:  Processed cyclic AMP-dependent transcription factor ATF-6 alpha.
Gene name:  ATF6
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
GO biological process 
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
1
  • TASBHF-UCL
Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responsedefinition[GO:0006990]  
1
  • TASPINC
Protein foldingdefinition[GO:0006457]  
1
  • TASPINC
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Response to stressdefinition[GO:0006950]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+22926  
Protein processing in endoplasmic reticulum  hsa04141+22926  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATF6
GenomeRNAi: 22926
PRO: PR:P18850