LIG1 - DNA ligase 1 - human protein (Function)
 
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Protein
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References

 
LIG1 »  DNA ligase 1   [ EC 6.5.1.1 ]
 
Protein also known as:  Polydeoxyribonucleotide synthase [ATP] 1.
Gene name:  LIG1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 108 1
GENE REF ISO

Function

 show evidences
Overview 
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
DNA ligase (ATP) activitydefinition[GO:0003910] silver  
  • IBARefGenome
DNA ligase activitydefinition[GO:0003909]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • TASPINC
Cell divisiondefinition[GO:0051301]  
  • IEAUniProtKB KW
DNA ligation involved in DNA repairdefinition[GO:0051103] silver  
  • IEAInterPro 2 GO
DNA metabolic processdefinition[GO:0006259]  
1
  • TASPINC
Double-strand break repair via nonhomologous end joiningdefinition[GO:0006303] silver  
  • IEAOrtholog Compara
Lagging strand elongationdefinition[GO:0006273] silver  
  • IBARefGenome
Not  Nucleotide-excision repairdefinition[GO:0006289] silver  
  • IBARefGenome
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Not  V(D)J recombinationdefinition[GO:0033151]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.5.1.1: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) AMP + diphosphate + (deoxyribonucleotide)(n+m).  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Base excision repair  hsa03410+3978  
DNA replication  hsa03030+3978  
Mismatch repair  hsa03430+3978  
Nucleotide excision repair  hsa03420+3978  
According to Reactome, this protein belongs to the following pathways:
Gap-filling DNA repair synthesis and ligation in GG-NER  REACT_1998  
Gap-filling DNA repair synthesis and ligation in TC-NER  REACT_74  
Processive synthesis on the C-strand of the telomere  REACT_8027  
Processive synthesis on the lagging strand  REACT_1385  
Removal of DNA patch containing abasic residue  REACT_2192  
Resolution of AP sites via the multiple-nucleotide patch replacement pathway  REACT_1128  
Resolution of D-loop structures through Holliday junction intermediates  REACT_977  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
DNA replication  definition   [KW-0235]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LIG1
GenomeRNAi: 3978
PRO: PR:P18858