XRCC1 - DNA repair protein XRCC1 - human protein (Function)
 
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Protein
Gene
References

 
XRCC1 »  DNA repair protein XRCC1
 
Protein also known as:  X-ray repair cross-complementing protein 1.
Gene name:  XRCC1
Entry whose protein(s) existence is based on evidence at protein level
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1 410 1
GENE REF ISO

Function

 show evidences
Overview 
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.  
  • CuratedUniProtKB
GO molecular function 
Damaged DNA bindingdefinition[GO:0003684] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
13
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Base-excision repairdefinition[GO:0006284] silver  
  • IBARefGenome
Hippocampus developmentdefinition[GO:0021766] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to organic substancedefinition[GO:0010033] silver  
  • IEAOrtholog Compara
Single strand break repairdefinition[GO:0000012] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Base excision repair  hsa03410+7515  
According to Reactome, this protein belongs to the following pathway:
Resolution of AP sites via the single-nucleotide replacement pathway  REACT_933  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: XRCC1
GenomeRNAi: 7515
PRO: PR:P18887