CDH2 - Cadherin-2 - human protein (Function)
 
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Protein
Gene
References

 
CDH2 »  Cadherin-2
 
Protein also known as:  Neural cadherin (N-cadherin); CD antigen CD325.
Gene name:  CDH2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).  
1
  • UniProtKB
GO molecular function 
Alpha-catenin bindingdefinition[GO:0045294]  
1
  • BHF-UCL
Beta-catenin bindingdefinition[GO:0008013]  
1
  • AgBase
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Gamma-catenin bindingdefinition[GO:0045295]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein phosphatase bindingdefinition[GO:0019903] silver  
1
  • Ortholog Compara
GO biological process 
Blood vessel morphogenesisdefinition[GO:0048514] silver  
1
  • Ortholog Compara
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesdefinition[GO:0016339] silver  
1
  • Ortholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • PINC
Cell migrationdefinition[GO:0016477] silver  
1
  • Ortholog Compara
Cell-cell adhesion mediated by cadherindefinition[GO:0044331]  
1
  • Ortholog Curator
Glial cell differentiationdefinition[GO:0010001]  
1
  • Ortholog Curator
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesdefinition[GO:0007157] silver  
1
  • Ortholog Compara
Homophilic cell adhesion via plasma membrane adhesion moleculesdefinition[GO:0007156] silver  
1
  • Ortholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090] silver  
1
  • Ortholog Compara
Neuronal stem cell maintenancedefinition[GO:0097150]  
1
  • Ortholog Curator
Positive regulation of MAPK cascadedefinition[GO:0043410] silver  
1
  • Ortholog Compara
Striated muscle cell differentiationdefinition[GO:0051146] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+1000  
Cell adhesion molecules (CAMs)  hsa04514+1000  
According to Reactome, this protein belongs to the following pathways:
Adherens junctions interactions  REACT_19195  
CDO in myogenesis  REACT_21402  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDH2
GenomeRNAi: 1000
PRO: PR:P19022