GNAZ - Guanine nucleotide-binding protein G(z) subunit alpha - human protein (Function)
 
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GNAZ »  Guanine nucleotide-binding protein G(z) subunit alpha
 
Protein also known as:  G(x) alpha chain.
Gene name:  GNAZ
Family name: G-alpha » G(i/o/t/z)
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  
1
  • UniProtKB
GO molecular function 
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683]  
1
  • RefGenome
G-protein coupled serotonin receptor bindingdefinition[GO:0031821]  
1
  • RefGenome
GTP bindingdefinition[GO:0005525]  
1
  • UniProtKB KW
GTPase activitydefinition[GO:0003924]  
1
  • RefGenome
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Receptor signaling protein activitydefinition[GO:0005057]  
1
  • PINC
Signal transducer activitydefinition[GO:0004871]  
1
  • RefGenome
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193] silver  
1
  • Ortholog Compara
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • RefGenome
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
GTP catabolic processdefinition[GO:0006184] silver  
1
  • InterPro 2 GO
Intracellular signal transductiondefinition[GO:0035556]  
1
  • GOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Long-term depression  hsa04730+2781  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
G-protein activation  REACT_15457  
PLC beta mediated events  REACT_15426  
 

Keywords

Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNAZ
GenomeRNAi: 2781
PRO: PR:P19086