HDC - Histidine decarboxylase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
HDC »  Histidine decarboxylase   [ EC 4.1.1.22 ]  (HDC)
 
Gene name:  HDC
Family name: Group II decarboxylase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 49 2
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the biosynthesis of histamine from histidine.  
2
  • UniProtKB
GO molecular function 
Histidine decarboxylase activitydefinition[GO:0004398]  
1
  • UniProtKB
Pyridoxal phosphate bindingdefinition[GO:0030170] silver  
1
  • InterPro 2 GO
GO biological process 
Catecholamine biosynthetic processdefinition[GO:0042423]  
1
  • UniProtKB KW
Histamine biosynthetic processdefinition[GO:0001694]  
2
  • UniProtKB
  • UniPathway
Histidine catabolic processdefinition[GO:0006548]  
1
  • UniProtKB
Histidine metabolic processdefinition[GO:0006547]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.1.22: L-histidine histamine + CO(2).  
2
  • UniProtKB
It requires the following cofactor
 pyridoxal 5'-phosphate  
2
  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Histidine metabolism  hsa00340+3067  
Metabolic pathways  hsa01100+3067  
According to Reactome, this protein belongs to the following pathway:
Histidine catabolism  REACT_1249  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 0.1 mM for histidine
Vmax 1880 nmol/min/mg enzyme

Keywords

Biological process 
Catecholamine biosynthesis  definition   [KW-0127]
Molecular function 
Decarboxylase  definition   [KW-0210]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Histidine_decarboxylase
GenomeRNAi: 3067
PRO: PR:P19113
Chemistry
GuidetoPHARMACOLOGY: 1274