HDC - Histidine decarboxylase - human protein (Function)
 
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HDC »  Histidine decarboxylase   [ EC 4.1.1.22 ]  (HDC)
 
Gene name:  HDC
Family name: Group II decarboxylase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the biosynthesis of histamine from histidine.  
1
  • CuratedUniProtKB
GO molecular function 
Histidine decarboxylase activitydefinition[GO:0004398]  
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  • IDAUniProtKB
Pyridoxal phosphate bindingdefinition[GO:0030170] silver  
  • IEAInterPro 2 GO
GO biological process 
Catecholamine biosynthetic processdefinition[GO:0042423]  
  • IEAUniProtKB KW
Histamine biosynthetic processdefinition[GO:0001694]  
1
  • IDAUniProtKB
  • IEAUniPathway
Histidine catabolic processdefinition[GO:0006548]  
1
  • IDAUniProtKB
Histidine metabolic processdefinition[GO:0006547]  
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  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.1.22: L-histidine histamine + CO(2).  
1
  • CuratedUniProtKB
It requires the following cofactor
Pyridoxal phosphate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Histidine metabolism  hsa00340+3067  
Metabolic pathways  hsa01100+3067  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Biophysicochemical properties

Kinetic parameters
KM 0.1 mM for histidine
Vmax 1880 nmol/min/mg enzyme

Keywords

Biological process 
Catecholamine biosynthesis  definition   [KW-0127]
Molecular function 
Decarboxylase  definition   [KW-0210]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Histidine_decarboxylase
GenomeRNAi: 3067
PRO: PR:P19113
Chemistry
GuidetoPHARMACOLOGY: 1274