PLCG1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 - human protein (Function)
 
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PLCG1 »  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1   [ EC 3.1.4.11 ]
 
Protein also known as:  Phosphoinositide phospholipase C-gamma-1.
Gene name:  PLCG1
Entry whose protein(s) existence is based on evidence at protein level
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1 213 2
GENE REF ISO

Function

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Overview 
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.  
2
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Glutamate receptor bindingdefinition[GO:0035254] silver  
1
  • Ortholog Compara
Neurotrophin TRKA receptor bindingdefinition[GO:0005168]  
1
  • UniProtKB
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
38
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • BHF-UCL
Receptor signaling protein activitydefinition[GO:0005057]  
1
  • UniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971] silver  
1
  • Ortholog Compara
GO biological process 
Calcium-mediated signalingdefinition[GO:0019722]  
1
  • BHF-UCL
Cell migrationdefinition[GO:0016477]  
1
  • BHF-UCL
Cellular response to epidermal growth factor stimulusdefinition[GO:0071364]  
2
  • BHF-UCL
  • UniProtKB
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • BHF-UCL
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Phospholipid catabolic processdefinition[GO:0009395] silver  
1
  • InterPro 2 GO
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • DFLAT
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
1
  • DFLAT
Positive regulation of epithelial cell migrationdefinition[GO:0010634]  
1
  • UniProtKB
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281]  
1
  • BHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.4.11: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.  
1
  • UniProtKB
It requires the following cofactor
 Ca(2+)  
1
  • UniProtKB
It is regulated in the following manner
Activated by phosphorylation on tyrosine residues.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+5335  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+5335  
ErbB signaling pathway  hsa04012+5335  
Fc epsilon RI signaling pathway  hsa04664+5335  
Fc gamma R-mediated phagocytosis  hsa04666+5335  
Glioma  hsa05214+5335  
Inositol phosphate metabolism  hsa00562+5335  
Leukocyte transendothelial migration  hsa04670+5335  
Metabolic pathways  hsa01100+5335  
Natural killer cell mediated cytotoxicity  hsa04650+5335  
Neurotrophin signaling pathway  hsa04722+5335  
Non-small cell lung cancer  hsa05223+5335  
Pathways in cancer  hsa05200+5335  
Phosphatidylinositol signaling system  hsa04070+5335  
T cell receptor signaling pathway  hsa04660+5335  
VEGF signaling pathway  hsa04370+5335  
Vibrio cholerae infection  hsa05110+5335  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  R-HSA-983695  
Constitutive Signaling by EGFRvIII  R-HSA-5637810  
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants  R-HSA-1236382  
DAG and IP3 signaling  R-HSA-1489509  
DAP12 signaling  R-HSA-2424491  
Downstream signal transduction  R-HSA-186763  
EGFR interacts with phospholipase C-gamma  R-HSA-212718  
FCERI mediated Ca+2 mobilization  R-HSA-2871809  
FCERI mediated MAPK activation  R-HSA-2871796  
Frs2-mediated activation  R-HSA-170968  
Generation of second messenger molecules  R-HSA-202433  
ISG15 antiviral mechanism  R-HSA-1169408  
PECAM1 interactions  R-HSA-210990  
Phospholipase C-mediated cascade, FGFR2  R-HSA-5654221  
Phospholipase C-mediated cascade, FGFR3  R-HSA-5654227  
Phospholipase C-mediated cascade, FGFR4  R-HSA-5654228  
Phospholipase C-mediated cascade: FGFR1  R-HSA-5654219  
PLC-gamma1 signalling  R-HSA-167021  
PLCG1 events in ERBB2 signaling  R-HSA-1251932  
Role of phospholipids in phagocytosis  R-HSA-2029485  
Role of second messengers in netrin-1 signaling  R-HSA-418890  
Signaling by FGFR1 in disease  R-HSA-5655302  
Signaling by FGFR2 in disease  R-HSA-5655253  
Signaling by FGFR3 in disease  R-HSA-5655332  
Signaling by FGFR4 in disease  R-HSA-5655291  
Synthesis of IP3 and IP4 in the cytosol  R-HSA-1855204  
VEGFR2 mediated cell proliferation  R-HSA-5218921  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PLCG1
GenomeRNAi: 5335
PRO: PR:P19174