EPOR - Erythropoietin receptor - human protein (Function)
 
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EPOR »  Erythropoietin receptor  (EPO-R)
 
Gene name:  EPOR
Entry whose protein(s) existence is based on evidence at protein level
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1 148 3
GENE REF ISO

Function

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Overview 
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.  
  • CuratedUniProtKB
Isoform  EPOR-T   Acts as a dominant-negative receptor of EPOR-mediated signaling.  
  • CuratedUniProtKB
GO molecular function 
Erythropoietin receptor activitydefinition[GO:0004900]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Decidualizationdefinition[GO:0046697] silver  
  • IEAOrtholog Compara
Embryo developmentdefinition[GO:0009790] silver  
  • IEAOrtholog Compara
Erythropoietin-mediated signaling pathwaydefinition[GO:0038162]  
2
  • TASGOC
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+2057  
Hematopoietic cell lineage  hsa04640+2057  
Jak-STAT signaling pathway  hsa04630+2057  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Erythropoietin_receptor
GenomeRNAi: 2057
PRO: PR:P19235
Chemistry
GuidetoPHARMACOLOGY: 1718