HK1 - Hexokinase-1 - human protein (Function)
 
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HK1 »  Hexokinase-1   [ EC 2.7.1.1 ]
 
Protein also known as:  Brain form hexokinase.
Gene name:  HK1
Family name: Hexokinase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Fructokinase activitydefinition[GO:0008865]  
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  • RefGenome
Glucokinase activitydefinition[GO:0004340]  
1
  • RefGenome
Hexokinase activitydefinition[GO:0004396]  
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  • PINC
Mannokinase activitydefinition[GO:0019158]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
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  • IntAct
GO biological process 
Carbohydrate phosphorylationdefinition[GO:0046835]  
4
  • GOC
  • InterPro 2 GO
  • RefGenome
  • EC 2 GO
Cellular glucose homeostasisdefinition[GO:0001678]  
1
  • RefGenome
Glucose 6-phosphate metabolic processdefinition[GO:0051156]  
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  • RefGenome
Glycolytic processdefinition[GO:0006096]  
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  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.1: ATP + D-hexose ADP + D-hexose 6-phosphate.  
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  • UniProtKB
It is regulated in the following manner
Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.  
1
  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Carbohydrate metabolism; hexose metabolism  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Amino sugar and nucleotide sugar metabolism  hsa00520+3098  
Butirosin and neomycin biosynthesis  hsa00524+3098  
Carbohydrate digestion and absorption  hsa04973+3098  
Fructose and mannose metabolism  hsa00051+3098  
Galactose metabolism  hsa00052+3098  
Glycolysis / Gluconeogenesis  hsa00010+3098  
Insulin signaling pathway  hsa04910+3098  
Metabolic pathways  hsa01100+3098  
Starch and sucrose metabolism  hsa00500+3098  
Type II diabetes mellitus  hsa04930+3098  
According to Reactome, this protein belongs to the following pathway:
Glucose transport  REACT_212  
 
More information is available from:
Note 
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).  
1
  • UniProtKB
 

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P19367
Other
GenomeRNAi: 3098
PRO: PR:P19367