TNNI3 - Troponin I, cardiac muscle - human protein (Function)
 
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TNNI3 »  Troponin I, cardiac muscle
 
Protein also known as:  Cardiac troponin I.
Gene name:  TNNI3
Family name: Troponin I
Entry whose protein(s) existence is based on evidence at protein level
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1 179 1
GENE REF ISO

Function

 show evidences
Overview 
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAUniProtKB
Calcium channel inhibitor activitydefinition[GO:0019855]  
1
  • IPIUniProtKB
Calcium-dependent protein bindingdefinition[GO:0048306]  
1
  • IPIUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
6
  • IPIUniProtKB
  • IPIIntAct
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Troponin C bindingdefinition[GO:0030172]  
3
  • IPIUniProtKB
Troponin T bindingdefinition[GO:0031014]  
1
  • IPIUniProtKB
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • IMPUniProtKB
Cellular calcium ion homeostasisdefinition[GO:0006874]  
  • ISSOrtholog Curator
Heart contractiondefinition[GO:0060047]  
1
  • IMPUniProtKB
Heart developmentdefinition[GO:0007507]  
  • ISSOrtholog Curator
Negative regulation of ATPase activitydefinition[GO:0032780]  
3
  • IDAUniProtKB
Regulation of smooth muscle contractiondefinition[GO:0006940] silver  
  • IEAOrtholog Compara
Regulation of systemic arterial blood pressure by ischemic conditionsdefinition[GO:0001980]  
  • ISSOrtholog Curator
Vasculogenesisdefinition[GO:0001570]  
  • ISSOrtholog Curator
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
2
  • IMPBHF-UCL
  • IMPHGNC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cardiac muscle contraction  hsa04260+7137  
Dilated cardiomyopathy  hsa05414+7137  
Hypertrophic cardiomyopathy (HCM)  hsa05410+7137  
According to Reactome, this protein belongs to the following pathway:
Muscle contraction  REACT_17044  
 

Keywords

Molecular function 
Muscle protein  definition   [KW-0514]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TNNI3
GenomeRNAi: 7137
PRO: PR:P19429