ERCC3 - TFIIH basal transcription factor complex helicase XPB subunit - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
ERCC3 »  TFIIH basal transcription factor complex helicase XPB subunit   [ EC 3.6.4.12 ]
 
Protein also known as:  TFIIH basal transcription factor complex 89 kDa subunit (TFIIH p89).
Gene name:  ERCC3
Family name: Helicase » RAD25/XPB
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 89 1
GENE REF ISO

Function

 show evidences
Overview 
ATP-dependent 3'-5' DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.  
3
  • UniProtKB
GO molecular function 
3'-5' DNA helicase activitydefinition[GO:0043138]  
2
  • UniProtKB
ATP bindingdefinition[GO:0005524] silver  
1
  • Ortholog Compara
ATP-dependent DNA helicase activitydefinition[GO:0004003] silver  
1
  • Ortholog Compara
ATPase activitydefinition[GO:0016887]  
1
  • UniProtKB
Damaged DNA bindingdefinition[GO:0003684]  
1
  • UniProtKB
dATP bindingdefinition[GO:0032564] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Contributes to DNA-dependent ATPase activitydefinition[GO:0008094]  
2
  • UniProtKB
GTP bindingdefinition[GO:0005525] silver  
1
  • Ortholog Compara
Peptide bindingdefinition[GO:0042277] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
2
  • UniProtKB
Contributes to protein kinase activitydefinition[GO:0004672]  
1
  • UniProtKB
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • UniProtKB
Contributes to RNA polymerase II carboxy-terminal domain kinase activitydefinition[GO:0008353]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • MGI
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
DNA repairdefinition[GO:0006281]  
1
  • UniProtKB
DNA topological changedefinition[GO:0006265]  
1
  • UniProtKB
Hair cell differentiationdefinition[GO:0035315]  
1
  • UniProtKB
Nucleotide-excision repairdefinition[GO:0006289]  
1
  • UniProtKB
Nucleotide-excision repair, DNA duplex unwindingdefinition[GO:0000717]  
1
  • UniProtKB
Nucleotide-excision repair, DNA incisiondefinition[GO:0033683]  
2
  • UniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Protein localizationdefinition[GO:0008104]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • Ortholog Compara
Regulation of mitotic cell cycle phase transitiondefinition[GO:1901990]  
1
  • UniProtKB
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to oxidative stressdefinition[GO:0006979]  
1
  • UniProtKB
Response to UVdefinition[GO:0009411]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
2
  • UniProtKB
Transcription-coupled nucleotide-excision repairdefinition[GO:0006283]  
1
  • UniProtKB
UV protectiondefinition[GO:0009650] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal transcription factors  hsa03022+2071  
Nucleotide excision repair  hsa03420+2071  
According to Reactome, this protein belongs to the following pathways:
Dual incision reaction in GG-NER  R-HSA-73941  
Dual incision reaction in TC-NER  R-HSA-110304  
Formation of HIV elongation complex in the absence of HIV Tat  R-HSA-167152  
Formation of HIV-1 elongation complex containing HIV-1 Tat  R-HSA-167200  
Formation of incision complex in GG-NER  R-HSA-73935  
Formation of RNA Pol II elongation complex  R-HSA-112382  
Formation of the Early Elongation Complex  R-HSA-113418  
Formation of the HIV-1 Early Elongation Complex  R-HSA-167158  
Formation of transcription-coupled NER (TC-NER) repair complex  R-HSA-110302  
HIV Transcription Initiation  R-HSA-167161  
mRNA Capping  R-HSA-72086  
NoRC negatively regulates rRNA expression  R-HSA-427413  
RNA Pol II CTD phosphorylation and interaction with CE  R-HSA-167160  
RNA Pol II CTD phosphorylation and interaction with CE  R-HSA-77075  
RNA Polymerase I Chain Elongation  R-HSA-73777  
RNA Polymerase I Promoter Escape  R-HSA-73772  
RNA Polymerase I Transcription Initiation  R-HSA-73762  
RNA Polymerase I Transcription Termination  R-HSA-73863  
RNA Polymerase II HIV Promoter Escape  R-HSA-167162  
RNA Polymerase II Pre-transcription Events  R-HSA-674695  
RNA Polymerase II Promoter Escape  R-HSA-73776  
RNA Polymerase II Transcription Elongation  R-HSA-75955  
RNA Polymerase II Transcription Initiation  R-HSA-75953  
RNA Polymerase II Transcription Initiation And Promoter Clearance  R-HSA-76042  
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening  R-HSA-73779  
Tat-mediated elongation of the HIV-1 transcript  R-HSA-167246  
Transcription of the HIV genome  R-HSA-167172  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: XPB
GenomeRNAi: 2071
PRO: PR:P19447