ERCC3 - TFIIH basal transcription factor complex helicase XPB subunit - human protein (Function)
 
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ERCC3 »  TFIIH basal transcription factor complex helicase XPB subunit   [ EC 3.6.4.12 ]
 
Protein also known as:  TFIIH basal transcription factor complex 89 kDa subunit (TFIIH p89).
Gene name:  ERCC3
Family name: Helicase » RAD25/XPB
Entry whose protein(s) existence is based on evidence at protein level
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1 77 1
GENE REF ISO

Function

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Overview 
ATP-dependent 3'-5' DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.  
3
  • UniProtKB
GO molecular function 
3'-5' DNA helicase activitydefinition[GO:0043138]  
2
  • UniProtKB
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATP-dependent DNA helicase activitydefinition[GO:0004003] silver  
1
  • InterPro 2 GO
ATPase activitydefinition[GO:0016887]  
1
  • UniProtKB
Damaged DNA bindingdefinition[GO:0003684]  
1
  • UniProtKB
dATP bindingdefinition[GO:0032564] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Contributes to DNA-dependent ATPase activitydefinition[GO:0008094]  
2
  • UniProtKB
GTP bindingdefinition[GO:0005525] silver  
1
  • Ortholog Compara
Peptide bindingdefinition[GO:0042277] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
8
  • UniProtKB
  • IntAct
Protein C-terminus bindingdefinition[GO:0008022]  
2
  • UniProtKB
Contributes to protein kinase activitydefinition[GO:0004672]  
1
  • UniProtKB
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • UniProtKB
Contributes to RNA polymerase II carboxy-terminal domain kinase activitydefinition[GO:0008353]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • MGI
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
ATP catabolic processdefinition[GO:0006200] silver  
1
  • Ortholog Compara
DNA repairdefinition[GO:0006281]  
1
  • UniProtKB
DNA topological changedefinition[GO:0006265]  
1
  • UniProtKB
Hair cell differentiationdefinition[GO:0035315]  
1
  • UniProtKB
Nucleotide-excision repairdefinition[GO:0006289]  
1
  • UniProtKB
Nucleotide-excision repair, DNA duplex unwindingdefinition[GO:0000717]  
1
  • UniProtKB
Nucleotide-excision repair, DNA incisiondefinition[GO:0033683]  
2
  • UniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Protein localizationdefinition[GO:0008104]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • Ortholog Compara
Regulation of mitotic cell cycle phase transitiondefinition[GO:1901990]  
1
  • UniProtKB
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to oxidative stressdefinition[GO:0006979]  
1
  • UniProtKB
Response to UVdefinition[GO:0009411]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
2
  • UniProtKB
Transcription-coupled nucleotide-excision repairdefinition[GO:0006283]  
1
  • UniProtKB
UV protectiondefinition[GO:0009650] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal transcription factors  hsa03022+2071  
Nucleotide excision repair  hsa03420+2071  
According to Reactome, this protein belongs to the following pathways:
Dual incision reaction in GG-NER  REACT_311  
Dual incision reaction in TC-NER  REACT_2222  
Formation of HIV elongation complex in the absence of HIV Tat  REACT_22201  
Formation of HIV-1 elongation complex containing HIV-1 Tat  REACT_6346  
Formation of incision complex in GG-NER  REACT_257  
Formation of the Early Elongation Complex  REACT_846  
Formation of the HIV-1 Early Elongation Complex  REACT_6319  
Formation of transcription-coupled NER (TC-NER) repair complex  REACT_1941  
HIV Transcription Initiation  REACT_6332  
mRNA Capping  REACT_1470  
NoRC negatively regulates rRNA expression  REACT_200856  
RNA Pol II CTD phosphorylation and interaction with CE  REACT_975  
RNA Pol II CTD phosphorylation and interaction with CE  REACT_6237  
RNA Polymerase I Chain Elongation  REACT_2204  
RNA Polymerase I Promoter Escape  REACT_1913  
RNA Polymerase I Transcription Initiation  REACT_953  
RNA Polymerase I Transcription Termination  REACT_1074  
RNA Polymerase II HIV Promoter Escape  REACT_6253  
RNA Polymerase II Pre-transcription Events  REACT_22107  
RNA Polymerase II Promoter Escape  REACT_2089  
RNA Polymerase II Transcription Elongation  REACT_833  
RNA Polymerase II Transcription Initiation  REACT_1851  
RNA Polymerase II Transcription Initiation And Promoter Clearance  REACT_834  
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening  REACT_1655  
Tat-mediated elongation of the HIV-1 transcript  REACT_6162  
Transcription of the HIV genome  REACT_6233  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: XPB
GenomeRNAi: 2071
PRO: PR:P19447