WT1 - Wilms tumor protein - human protein (Function)
 
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WT1 »  Wilms tumor protein
 
Protein also known as:  WT33.
Gene name:  WT1
Entry whose protein(s) existence is based on evidence at protein level
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1 141 8
GENE REF ISO

Function

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Overview 
Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing.  
2
  • UniProtKB
Isoform  Iso 1   Has lower affinity for DNA, and can bind RNA.  
3
  • UniProtKB
GO molecular function 
C2H2 zinc finger domain bindingdefinition[GO:0070742]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • UniProtKB
RNA bindingdefinition[GO:0003723]  
1
  • UniProtKB KW
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • Ortholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565]  
3
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
3
  • UniProtKB
  • Ortholog Curator
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
5
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • UniProtKB
GO biological process 
Adrenal cortex formationdefinition[GO:0035802]  
1
  • Ortholog Curator
Adrenal gland developmentdefinition[GO:0030325]  
1
  • UniProtKB
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
1
  • UniProtKB
Camera-type eye developmentdefinition[GO:0043010]  
1
  • Ortholog Curator
Cardiac muscle cell fate commitmentdefinition[GO:0060923]  
1
  • Ortholog Curator
Cellular response to cAMPdefinition[GO:0071320]  
1
  • UniProtKB
Cellular response to gonadotropin stimulusdefinition[GO:0071371]  
1
  • UniProtKB
Diaphragm developmentdefinition[GO:0060539]  
1
  • Ortholog Curator
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • Ortholog Curator
Germ cell developmentdefinition[GO:0007281]  
1
  • Ortholog Curator
Glomerular basement membrane developmentdefinition[GO:0032836]  
1
  • UniProtKB
Glomerular visceral epithelial cell differentiationdefinition[GO:0072112]  
2
  • RefGenome
  • Ortholog Curator
Glomerulus developmentdefinition[GO:0032835]  
1
  • UniProtKB
Gonad developmentdefinition[GO:0008406]  
1
  • Ortholog Curator
Heart developmentdefinition[GO:0007507]  
1
  • UniProtKB
Kidney developmentdefinition[GO:0001822]  
1
  • UniProtKB
Male genitalia developmentdefinition[GO:0030539]  
1
  • Ortholog Curator
Male gonad developmentdefinition[GO:0008584]  
1
  • UniProtKB
Mesenchymal to epithelial transitiondefinition[GO:0060231]  
1
  • Ortholog Curator
Metanephric epithelium developmentdefinition[GO:0072207]  
1
  • UniProtKB
Metanephric mesenchyme developmentdefinition[GO:0072075]  
1
  • Ortholog Curator
Metanephric S-shaped body morphogenesisdefinition[GO:0072284]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
3
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
2
  • UniProtKB
Negative regulation of female gonad developmentdefinition[GO:2000195]  
1
  • Ortholog Curator
Negative regulation of metanephric glomerular mesangial cell proliferationdefinition[GO:0072302]  
1
  • Ortholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • MGI
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
9
  • UniProtKB
Isoform  Iso 3   Negative regulation of translationdefinition[GO:0017148]  
1
  • UniProtKB
Isoform  Iso 3   Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Positive regulation of heart growthdefinition[GO:0060421]  
1
  • Ortholog Curator
Positive regulation of male gonad developmentdefinition[GO:2000020]  
1
  • Ortholog Curator
Positive regulation of metanephric ureteric bud developmentdefinition[GO:2001076]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • Ortholog Curator
Isoforms  Iso 2 , Iso 3 , Iso 4 , Iso 6 , Iso 7 , Iso 8 and Iso 9 but not isoform  Iso 1   Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
11
  • UniProtKB
Posterior mesonephric tubule developmentdefinition[GO:0072166]  
1
  • Ortholog Curator
Regulation of organ formationdefinition[GO:0003156]  
1
  • Ortholog Curator
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • Ortholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
3
  • UniProtKB
  • Ortholog Curator
RNA splicingdefinition[GO:0008380]  
1
  • Ortholog Curator
Sex determinationdefinition[GO:0007530]  
1
  • UniProtKB
Thorax and anterior abdomen determinationdefinition[GO:0007356]  
1
  • Ortholog Curator
Tissue developmentdefinition[GO:0009888]  
1
  • Ortholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Ureteric bud developmentdefinition[GO:0001657]  
1
  • Ortholog Curator
Vasculogenesisdefinition[GO:0001570]  
1
  • Ortholog Curator
Visceral serous pericardium developmentdefinition[GO:0061032]  
1
  • UniProtKB
Note 
Presence of the KTS motif hinders interactions between DNA and zinc-finger 4.  
1
  • UniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WT1
GenomeRNAi: 7490
PRO: PR:P19544