WT1 - Wilms tumor protein - human protein (Function)
 
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WT1 »  Wilms tumor protein
 
Protein also known as:  WT33.
Gene name:  WT1
Entry whose protein(s) existence is based on evidence at protein level
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1 135 8
GENE REF ISO

Function

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Overview 
Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing.  
2
  • CuratedUniProtKB
Isoform  Iso 1   Has lower affinity for DNA, and can bind RNA.  
2
  • CuratedUniProtKB
GO molecular function 
C2H2 zinc finger domain bindingdefinition[GO:0070742]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723]  
  • IEAUniProtKB KW
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
  • ISSOrtholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565]  
3
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • NASUniProtKB
  • ISSOrtholog Curator
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
5
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Adrenal cortex formationdefinition[GO:0035802]  
  • ISSOrtholog Curator
Adrenal gland developmentdefinition[GO:0030325]  
1
  • IGIUniProtKB
Isoform  Iso 3   Apoptotic DNA fragmentationdefinition[GO:0006309]  
1
  • IDAUniProtKB
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
1
  • IGIUniProtKB
Camera-type eye developmentdefinition[GO:0043010]  
  • ISSOrtholog Curator
Cardiac muscle cell fate commitmentdefinition[GO:0060923]  
  • ISSOrtholog Curator
Cellular response to cAMPdefinition[GO:0071320]  
1
  • IEPUniProtKB
Cellular response to gonadotropin stimulusdefinition[GO:0071371]  
1
  • IDAUniProtKB
Diaphragm developmentdefinition[GO:0060539]  
  • ISSOrtholog Curator
Epithelial cell differentiationdefinition[GO:0030855]  
  • ISSOrtholog Curator
Germ cell developmentdefinition[GO:0007281]  
  • ISSOrtholog Curator
Glomerular basement membrane developmentdefinition[GO:0032836]  
1
  • IMPUniProtKB
Glomerular visceral epithelial cell differentiationdefinition[GO:0072112]  
  • IBARefGenome
  • ISSOrtholog Curator
Glomerulus developmentdefinition[GO:0032835]  
1
  • IGIUniProtKB
Gonad developmentdefinition[GO:0008406]  
  • ISSOrtholog Curator
Heart developmentdefinition[GO:0007507]  
1
  • IGIUniProtKB
Kidney developmentdefinition[GO:0001822]  
1
  • IGIUniProtKB
Male genitalia developmentdefinition[GO:0030539]  
  • ISSOrtholog Curator
Male gonad developmentdefinition[GO:0008584]  
1
  • IEPUniProtKB
Mesenchymal to epithelial transitiondefinition[GO:0060231]  
  • ISSOrtholog Curator
Metanephric epithelium developmentdefinition[GO:0072207]  
1
  • IEPUniProtKB
Metanephric mesenchyme developmentdefinition[GO:0072075]  
  • ISSOrtholog Curator
Metanephric S-shaped body morphogenesisdefinition[GO:0072284]  
1
  • IGIUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IGIUniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
3
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
2
  • IDAUniProtKB
Negative regulation of female gonad developmentdefinition[GO:2000195]  
  • ISSOrtholog Curator
Negative regulation of metanephric glomerular mesangial cell proliferationdefinition[GO:0072302]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAMGI
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
9
  • IDAUniProtKB
Isoform  Iso 3   Negative regulation of translationdefinition[GO:0017148]  
1
  • IDAUniProtKB
Positive regulation of heart growthdefinition[GO:0060421]  
  • ISSOrtholog Curator
Positive regulation of male gonad developmentdefinition[GO:2000020]  
  • ISSOrtholog Curator
Positive regulation of metanephric ureteric bud developmentdefinition[GO:2001076]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Isoforms  Iso 2 , Iso 4 , Iso 6 , Iso 7 , Iso 8 and Iso 9 but not isoforms  Iso 1 and Iso 3   Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
11
  • IDAUniProtKB
Posterior mesonephric tubule developmentdefinition[GO:0072166]  
  • ISSOrtholog Curator
Regulation of organ formationdefinition[GO:0003156]  
  • ISSOrtholog Curator
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • NASUniProtKB
  • ISSOrtholog Curator
RNA splicingdefinition[GO:0008380]  
  • ISSOrtholog Curator
Sex determinationdefinition[GO:0007530]  
1
  • IDAUniProtKB
Thorax and anterior abdomen determinationdefinition[GO:0007356]  
  • ISSOrtholog Curator
Tissue developmentdefinition[GO:0009888]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Ureteric bud developmentdefinition[GO:0001657]  
  • ISSOrtholog Curator
Vasculogenesisdefinition[GO:0001570]  
  • ISSOrtholog Curator
Visceral serous pericardium developmentdefinition[GO:0061032]  
1
  • IGIUniProtKB
Note 
Presence of the KTS motif hinders interactions between DNA and zinc-finger 4.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WT1
GenomeRNAi: 7490
PRO: PR:P19544