RXRA - Retinoic acid receptor RXR-alpha - human protein (Function)
 
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RXRA »  Retinoic acid receptor RXR-alpha
 
Protein also known as:  Nuclear receptor subfamily 2 group B member 1.
Gene name:  RXRA
Family name: Nuclear hormone receptor » NR2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.  
4
  • CuratedUniProtKB
GO molecular function 
9-cis retinoic acid receptor activitydefinition[GO:0004886] silver  
  • IEAOrtholog Compara
Chromatin DNA bindingdefinition[GO:0031490] silver  
  • IEAOrtholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • IDAMGI
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
17
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAUniProtKB
Retinoic acid receptor activitydefinition[GO:0003708]  
1
  • TASBHF-UCL
Retinoic acid-responsive element bindingdefinition[GO:0044323]  
1
  • IDAUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Contributes to sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
3
  • IDAUniProtKB
  • IDABHF-UCL
  • IDAMGI
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAInterPro 2 GO
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
Contributes to transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDABHF-UCL
Vitamin D receptor bindingdefinition[GO:0042809]  
1
  • IPIBHF-UCL
Contributes to vitamin D response element bindingdefinition[GO:0070644]  
1
  • IDABHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cardiac muscle cell proliferationdefinition[GO:0060038] silver  
  • IEAOrtholog Compara
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • TASBHF-UCL
Embryo implantationdefinition[GO:0007566] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Maternal placenta developmentdefinition[GO:0001893] silver  
  • IEAOrtholog Compara
Modulation by virus of host morphology or physiologydefinition[GO:0019048]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
Peroxisome proliferator activated receptor signaling pathwaydefinition[GO:0035357]  
1
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDAUniProtKB
  • IDAMGI
Regulation of branching involved in prostate gland morphogenesisdefinition[GO:0060687] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526]  
1
  • IMPBHF-UCL
Retinoic acid receptor signaling pathwaydefinition[GO:0048384]  
1
  • IMPBHF-UCL
Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus developmentdefinition[GO:0060528] silver  
  • IEAOrtholog Compara
Ventricular cardiac muscle cell differentiationdefinition[GO:0055012] silver  
  • IEAOrtholog Compara
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010] silver  
  • IEAOrtholog Compara
Vitamin metabolic processdefinition[GO:0006766]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+6256  
Bile secretion  hsa04976+6256  
Hepatitis C  hsa05160+6256  
Non-small cell lung cancer  hsa05223+6256  
Pathways in cancer  hsa05200+6256  
PPAR signaling pathway  hsa03320+6256  
Small cell lung cancer  hsa05222+6256  
Thyroid cancer  hsa05216+6256  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Gene Expression  REACT_71  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Retinoid_X_receptor_alpha
GenomeRNAi: 6256
PRO: PR:P19793
Chemistry
GuidetoPHARMACOLOGY: 610