RXRA - Retinoic acid receptor RXR-alpha - human protein (Function)
 
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RXRA »  Retinoic acid receptor RXR-alpha
 
Protein also known as:  Nuclear receptor subfamily 2 group B member 1.
Gene name:  RXRA
Family name: Nuclear hormone receptor » NR2
Entry whose protein(s) existence is based on evidence at protein level
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1 226 2
GENE REF ISO

Function

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Overview 
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.  
5
  • UniProtKB
GO molecular function 
9-cis retinoic acid receptor activitydefinition[GO:0004886] silver  
1
  • Ortholog Compara
Chromatin DNA bindingdefinition[GO:0031490] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • MGI
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
19
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
Retinoic acid receptor activitydefinition[GO:0003708]  
1
  • BHF-UCL
Retinoic acid-responsive element bindingdefinition[GO:0044323]  
1
  • UniProtKB
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • MGI
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • AgBase
Contributes to sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
3
  • UniProtKB
  • BHF-UCL
  • MGI
Steroid hormone receptor activitydefinition[GO:0003707] silver  
1
  • InterPro 2 GO
Transcription coactivator activitydefinition[GO:0003713]  
1
  • PINC
Contributes to transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • BHF-UCL
Vitamin D receptor bindingdefinition[GO:0042809]  
1
  • BHF-UCL
Contributes to vitamin D response element bindingdefinition[GO:0070644]  
1
  • BHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Camera-type eye developmentdefinition[GO:0043010] silver  
1
  • Ortholog Compara
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • BHF-UCL
Embryo implantationdefinition[GO:0007566] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Maternal placenta developmentdefinition[GO:0001893] silver  
1
  • Ortholog Compara
Modulation by virus of host morphology or physiologydefinition[GO:0019048]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • BHF-UCL
Peroxisome proliferator activated receptor signaling pathwaydefinition[GO:0035357]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • UniProtKB
  • MGI
Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusdefinition[GO:1901522] silver  
1
  • Ortholog Compara
Positive regulation of translational initiation by irondefinition[GO:0045994] silver  
1
  • Ortholog Compara
Protein homotetramerizationdefinition[GO:0051289]  
1
  • MGI
Regulation of branching involved in prostate gland morphogenesisdefinition[GO:0060687] silver  
1
  • Ortholog Compara
Response to retinoic aciddefinition[GO:0032526]  
1
  • BHF-UCL
Retinoic acid receptor signaling pathwaydefinition[GO:0048384]  
1
  • BHF-UCL
Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus developmentdefinition[GO:0060528] silver  
1
  • Ortholog Compara
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Ventricular cardiac muscle cell differentiationdefinition[GO:0055012] silver  
1
  • Ortholog Compara
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010] silver  
1
  • Ortholog Compara
Vitamin metabolic processdefinition[GO:0006766]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+6256  
Bile secretion  hsa04976+6256  
Hepatitis C  hsa05160+6256  
Non-small cell lung cancer  hsa05223+6256  
Pathways in cancer  hsa05200+6256  
PPAR signaling pathway  hsa03320+6256  
Small cell lung cancer  hsa05222+6256  
Thyroid cancer  hsa05216+6256  
According to Reactome, this protein belongs to the following pathways:
Activation of gene expression by SREBF (SREBP)  REACT_147904  
BMAL1:CLOCK,NPAS2 activates circadian gene expression  REACT_111118  
Circadian Clock  REACT_24941  
Endogenous sterols  REACT_13812  
Import of palmitoyl-CoA into the mitochondrial matrix  REACT_11082  
Nuclear Receptor transcription pathway  REACT_15525  
Orphan transporters  REACT_268444  
PPARA activates gene expression  REACT_116145  
Recycling of bile acids and salts  REACT_11042  
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)  REACT_19241  
Regulation of pyruvate dehydrogenase (PDH) complex  REACT_12528  
REV-ERBA represses gene expression  REACT_118789  
RORA activates circadian gene expression  REACT_118659  
Signaling by Retinoic Acid  REACT_267785  
Synthesis of bile acids and bile salts  REACT_11054  
Synthesis of bile acids and bile salts via 27-hydroxycholesterol  REACT_11048  
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol  REACT_11041  
Transcriptional activation of mitochondrial biogenesis  REACT_264212  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
YAP1- and WWTR1 (TAZ)-stimulated gene expression  REACT_118713  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Retinoid_X_receptor_alpha
GenomeRNAi: 6256
PRO: PR:P19793
Chemistry
GuidetoPHARMACOLOGY: 610