AOC1 - Amiloride-sensitive amine oxidase [copper-containing] - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
AOC1 »  Amiloride-sensitive amine oxidase [copper-containing]   [ EC 1.4.3.22 ]  (DAO)
 
Protein also known as:  Amine oxidase copper domain-containing protein 1.
Gene name:  AOC1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 30 2
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.  
1
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
2
  • UniProtKB
Cation channel activitydefinition[GO:0005261]  
1
  • UniProtKB
Copper ion bindingdefinition[GO:0005507]  
2
  • UniProtKB
Diamine oxidase activitydefinition[GO:0052597]  
4
  • UniProtKB
Drug bindingdefinition[GO:0008144]  
2
  • UniProtKB
Heparin bindingdefinition[GO:0008201]  
2
  • UniProtKB
Histamine oxidase activitydefinition[GO:0052598]  
1
  • EC 2 GO
Methylputrescine oxidase activitydefinition[GO:0052599]  
1
  • EC 2 GO
Primary amine oxidase activitydefinition[GO:0008131]  
2
  • UniProtKB
  • MGI
Propane-1,3-diamine oxidase activitydefinition[GO:0052600]  
1
  • EC 2 GO
Protein complex bindingdefinition[GO:0032403]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Quinone bindingdefinition[GO:0048038]  
2
  • UniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • UniProtKB
Sodium channel activitydefinition[GO:0005272]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • UniProtKB
GO biological process 
Amine metabolic processdefinition[GO:0009308] silver  
1
  • InterPro 2 GO
Cellular response to azidedefinition[GO:0097185]  
1
  • UniProtKB
Cellular response to copper iondefinition[GO:0071280]  
1
  • UniProtKB
Cellular response to copper ion starvationdefinition[GO:0035874]  
1
  • UniProtKB
Cellular response to heparindefinition[GO:0071504]  
1
  • UniProtKB
Cellular response to histaminedefinition[GO:0071420]  
1
  • UniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
2
  • UniProtKB
Response to antibioticdefinition[GO:0046677]  
2
  • UniProtKB
Response to drugdefinition[GO:0042493]  
1
  • UniProtKB
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.4.3.22: Histamine + H(2)O + O(2) (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2).  
1
  • UniProtKB
It requires the following cofactors
 Cu cation : Binds 1 copper ion per subunit.  
2
  • UniProtKB
 Ca(2+) : Binds 2 calcium ions per subunit.  
2
  • UniProtKB
 L-topaquinone : Contains 1 topaquinone per subunit.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+26  
Histidine metabolism  hsa00340+26  
Tryptophan metabolism  hsa00380+26  
 
More information is available from:
Note 
Inhibited by amiloride in a competitive manner.  
1
  • UniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 26
PRO: PR:P19801