AOC1 - Amiloride-sensitive amine oxidase [copper-containing] - human protein (Function)
 
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References

 
AOC1 »  Amiloride-sensitive amine oxidase [copper-containing]   [ EC 1.4.3.22 ]  (DAO)
 
Protein also known as:  Amine oxidase copper domain-containing protein 1.
Gene name:  AOC1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 42 2
GENE REF ISO

Function

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Overview 
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
2
  • IDAUniProtKB
Cation channel activitydefinition[GO:0005261]  
1
  • IDAUniProtKB
Copper ion bindingdefinition[GO:0005507]  
2
  • IDAUniProtKB
Diamine oxidase activitydefinition[GO:0052597]  
4
  • IDAUniProtKB
Drug bindingdefinition[GO:0008144]  
2
  • IDAUniProtKB
Heparin bindingdefinition[GO:0008201]  
2
  • IDAUniProtKB
Histamine oxidase activitydefinition[GO:0052598]  
  • IEAEC 2 GO
Methylputrescine oxidase activitydefinition[GO:0052599]  
  • IEAEC 2 GO
Primary amine oxidase activitydefinition[GO:0008131]  
2
  • IDAUniProtKB
  • IDAMGI
Propane-1,3-diamine oxidase activitydefinition[GO:0052600]  
  • IEAEC 2 GO
Protein complex bindingdefinition[GO:0032403]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Quinone bindingdefinition[GO:0048038]  
2
  • IDAUniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • IDAUniProtKB
Sodium channel activitydefinition[GO:0005272]  
1
  • TASUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Amine metabolic processdefinition[GO:0009308] silver  
  • IEAInterPro 2 GO
Cellular response to azidedefinition[GO:0097185]  
1
  • IDAUniProtKB
Cellular response to copper iondefinition[GO:0071280]  
1
  • IDAUniProtKB
Cellular response to copper ion starvationdefinition[GO:0035874]  
1
  • IDAUniProtKB
Cellular response to heparindefinition[GO:0071504]  
1
  • TASUniProtKB
Cellular response to histaminedefinition[GO:0071420]  
1
  • IDAUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
2
  • IDAUniProtKB
Response to antibioticdefinition[GO:0046677]  
2
  • IDAUniProtKB
Response to drugdefinition[GO:0042493]  
1
  • IDAUniProtKB
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.4.3.22: Histamine + H(2)O + O(2) (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2).  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 copper ion per subunit.  
1
  • CuratedUniProtKB
Binds 2 calcium ions per subunit.  
1
  • CuratedUniProtKB
Contains 1 topaquinone per subunit.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+26  
Histidine metabolism  hsa00340+26  
Tryptophan metabolism  hsa00380+26  
Note 
Inhibited by amiloride in a competitive manner (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 26
PRO: PR:P19801