CXCL3 - C-X-C motif chemokine 3 - human protein (Function)
 
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Protein
Gene
References

 
CXCL3 »  C-X-C motif chemokine 3
 
Protein also known as:  Macrophage inflammatory protein 2-beta (MIP2-beta). Cleaved into:  GRO-gamma(5-73).
Gene name:  CXCL3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.  
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  • CuratedUniProtKB
GO molecular function 
Chemokine activitydefinition[GO:0008009]  
  • ISSOrtholog Curator
GO biological process 
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Neutrophil chemotaxisdefinition[GO:0030593]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2921  
Cytokine-cytokine receptor interaction  hsa04060+2921  
Legionellosis  hsa05134+2921  
Salmonella infection  hsa05132+2921  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Inflammatory response  definition   [KW-0395]
Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CXCL3
GenomeRNAi: 2921
PRO: PR:P19876