NCF2 - Neutrophil cytosol factor 2 - human protein (Function)
 
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Protein
Gene
References

 
NCF2 »  Neutrophil cytosol factor 2
 
Gene name:  NCF2
Family name: NCF2/NOXA1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).  
1
  • CuratedUniProtKB
GO molecular function 
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIBHF-UCL
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Rac GTPase bindingdefinition[GO:0048365] silver  
  • IEAOrtholog Compara
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Cellular response to hormone stimulusdefinition[GO:0032870] silver  
  • IEAOrtholog Compara
Innate immune responsedefinition[GO:0045087]  
1
  • TASBHF-UCL
Positive regulation of blood pressuredefinition[GO:0045777] silver  
  • IEAOrtholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Respiratory burstdefinition[GO:0045730]  
1
  • TASBHF-UCL
Response to activitydefinition[GO:0014823] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to hyperoxiadefinition[GO:0055093] silver  
  • IEAOrtholog Compara
Response to laminar fluid shear stressdefinition[GO:0034616] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to progesteronedefinition[GO:0032570] silver  
  • IEAOrtholog Compara
Superoxide anion generationdefinition[GO:0042554]  
1
  • TASBHF-UCL
Superoxide metabolic processdefinition[GO:0006801]  
1
  • TASBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Leishmaniasis  hsa05140+4688  
Leukocyte transendothelial migration  hsa04670+4688  
Osteoclast differentiation  hsa04380+4688  
Phagosome  hsa04145+4688  
According to Reactome, this protein belongs to the following pathways:
Cross-presentation of particulate exogenous antigens (phagosomes)  REACT_111174  
Phagosomal maturation (early endosomal stage)  REACT_121256  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links