FST - Follistatin - human protein (Function)
 
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FST »  Follistatin  (FS)
 
Protein also known as:  Activin-binding protein.
Gene name:  FST
Entry whose protein(s) existence is based on evidence at protein level
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1 76 2
GENE REF ISO

Function

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Overview 
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).  
  • CuratedUniProtKB
GO molecular function 
Activin bindingdefinition[GO:0048185]  
1
  • IPIUniProtKB
Heparan sulfate proteoglycan bindingdefinition[GO:0043395] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Signal transducer activitydefinition[GO:0004871]  
1
  • NASUniProtKB
GO biological process 
BMP signaling pathwaydefinition[GO:0030509] silver  
  • IEAOrtholog Compara
Female gonad developmentdefinition[GO:0008585] silver  
  • IEAOrtholog Compara
Gamete generationdefinition[GO:0007276] silver  
  • IEAOrtholog Compara
Hair follicle morphogenesisdefinition[GO:0031069] silver  
  • IEAOrtholog Compara
Hematopoietic progenitor cell differentiationdefinition[GO:0002244]  
1
  • IDAUniProtKB
Keratinocyte proliferationdefinition[GO:0043616] silver  
  • IEAOrtholog Compara
Negative regulation of activin receptor signaling pathwaydefinition[GO:0032926]  
2
  • IDAUniProtKB
Negative regulation of cell differentiationdefinition[GO:0045596] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Pattern specification processdefinition[GO:0007389] silver  
  • IEAOrtholog Compara
Positive regulation of hair follicle developmentdefinition[GO:0051798]  
1
  • IDAMGI
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+10468  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Follistatin
GenomeRNAi: 10468
PRO: PR:P19883