TYMP - Thymidine phosphorylase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
TYMP »  Thymidine phosphorylase   [ EC 2.4.2.4 ]  (TP)
 
Protein also known as:  Platelet-derived endothelial cell growth factor (PD-ECGF).
Gene name:  TYMP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 126 2
GENE REF ISO

Function

 show evidences
Overview 
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.  
1
  • CuratedUniProtKB
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.  
1
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Phosphorylase activitydefinition[GO:0004645] silver  
  • IEAInterPro 2 GO
Platelet-derived growth factor receptor bindingdefinition[GO:0005161]  
1
  • TASPINC
Pyrimidine-nucleoside phosphorylase activitydefinition[GO:0016154] silver  
  • IEAInterPro 2 GO
Thymidine phosphorylase activitydefinition[GO:0009032]  
  • IEAEC 2 GO
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Chemotaxisdefinition[GO:0006935]  
  • IEAUniProtKB KW
DNA replicationdefinition[GO:0006260]  
1
  • TASPINC
Mitochondrial genome maintenancedefinition[GO:0000002]  
1
  • TASPINC
Pyrimidine nucleotide metabolic processdefinition[GO:0006220]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.2.4: Thymidine + phosphate thymine + 2-deoxy-alpha-D-ribose 1-phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Bladder cancer  hsa05219+1890  
Drug metabolism - other enzymes  hsa00983+1890  
Metabolic pathways  hsa01100+1890  
Pyrimidine metabolism  hsa00240+1890  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Chemotaxis  definition   [KW-0145]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Glycosyltransferase  definition   [KW-0328]
Growth factor  definition   [KW-0339]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P19971
Other
GeneWiki: ECGF1
GenomeRNAi: 1890
PRO: PR:P19971