ATP2B1 - Plasma membrane calcium-transporting ATPase 1 - human protein (Function)
 
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ATP2B1 »  Plasma membrane calcium-transporting ATPase 1   [ EC 3.6.3.8 ]  (PMCA1)
 
Protein also known as:  Plasma membrane calcium ATPase isoform 1.
Gene name:  ATP2B1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.2.25  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium-transporting ATPase activitydefinition[GO:0005388]  
  • IEAEC 2 GO
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Isoform  B   Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • TASGOC
Metabolic processdefinition[GO:0008152]  
1
  • TASGOC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.8: ATP + H(2)O + Ca(2+)(Side 1) ADP + phosphate + Ca(2+)(Side 2).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+490  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+490  
Mineral absorption  hsa04978+490  
Pancreatic secretion  hsa04972+490  
Salivary secretion  hsa04970+490  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP2B1
GenomeRNAi: 490
PRO: PR:P20020