CD33 - Myeloid cell surface antigen CD33 - human protein (Function)
 
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Protein
Gene
References

 
CD33 »  Myeloid cell surface antigen CD33
 
Protein also known as:  Sialic acid-binding Ig-like lectin 3 (Siglec-3); CD antigen CD33.
Gene name:  CD33
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 58 3
GENE REF ISO

Function

 show evidences
Overview 
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Hematopoietic cell lineage  hsa04640+945  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 945
PRO: PR:P20138
Chemistry
GuidetoPHARMACOLOGY: 2601