AZU1 - Azurocidin - human protein (Function)
 
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AZU1 »  Azurocidin
 
Gene name:  AZU1
Family name: Peptidase S1 » Elastase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.  
2
  • CuratedUniProtKB
GO molecular function 
Heparin bindingdefinition[GO:0008201]  
1
  • NASUniProtKB
Not  Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IBARefGenome
Toxic substance bindingdefinition[GO:0015643]  
1
  • NASUniProtKB
GO biological process 
Cellular extravasationdefinition[GO:0045123]  
1
  • NASUniProtKB
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
1
  • TASUniProtKB
Glial cell migrationdefinition[GO:0008347]  
1
  • IDAUniProtKB
Induction of positive chemotaxisdefinition[GO:0050930]  
1
  • NASUniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • NASUniProtKB
Macrophage chemotaxisdefinition[GO:0048246]  
1
  • NASUniProtKB
Microglial cell activationdefinition[GO:0001774]  
1
  • IEPUniProtKB
Monocyte activationdefinition[GO:0042117]  
1
  • TASUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • NASUniProtKB
Positive regulation of cell adhesiondefinition[GO:0045785]  
1
  • IDAUniProtKB
Positive regulation of fractalkine biosynthetic processdefinition[GO:0050754]  
1
  • IDAUniProtKB
Positive regulation of interleukin-1 beta biosynthetic processdefinition[GO:0050725]  
1
  • IDAUniProtKB
Positive regulation of MHC class II biosynthetic processdefinition[GO:0045348]  
1
  • IEPUniProtKB
Positive regulation of phagocytosisdefinition[GO:0050766]  
1
  • IDAUniProtKB
Positive regulation of tumor necrosis factor biosynthetic processdefinition[GO:0042535]  
1
  • IDAUniProtKB
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205]  
1
  • TASUniProtKB
Proteolysisdefinition[GO:0006508] silver  
  • IBARefGenome
Regulation of vascular permeabilitydefinition[GO:0043114]  
1
  • NASUniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
Antibiotic  definition   [KW-0044]
Antimicrobial  definition   [KW-0929]
Serine protease homolog  definition   [KW-0721]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Azurocidin_1
GenomeRNAi: 566
PRO: PR:P20160