POU3F3 - POU domain, class 3, transcription factor 3 - human protein (Function)
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POU3F3 »  POU domain, class 3, transcription factor 3
Protein also known as:  Brain-specific homeobox/POU domain protein 1 (Brn-1).
Gene name:  POU3F3
Entry whose protein(s) existence is based on evidence at transcript level
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Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).  
  • CuratedUniProtKB
GO molecular function 
HMG box domain bindingdefinition[GO:0071837] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Central nervous system developmentdefinition[GO:0007417]  
Cerebral cortex radially oriented cell migrationdefinition[GO:0021799] silver  
  • IEAOrtholog Compara
Forebrain ventricular zone progenitor cell divisiondefinition[GO:0021869] silver  
  • IEAOrtholog Compara
Metanephric ascending thin limb developmentdefinition[GO:0072218]  
  • ISSOrtholog Curator
Metanephric DCT cell differentiationdefinition[GO:0072240]  
  • ISSOrtholog Curator
Metanephric loop of Henle developmentdefinition[GO:0072236]  
  • ISSOrtholog Curator
Metanephric macula densa developmentdefinition[GO:0072227]  
  • ISSOrtholog Curator
Metanephric thick ascending limb developmentdefinition[GO:0072233]  
  • ISSOrtholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066]  
  • ISSOrtholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
  • ISSOrtholog Curator
Positive regulation of gene expressiondefinition[GO:0010628]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW


Biological process 
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 5455
PRO: PR:P20264