CD22 - B-cell receptor CD22 - human protein (Function)
 
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Protein
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References

 
CD22 »  B-cell receptor CD22
 
Protein also known as:  Sialic acid-binding Ig-like lectin 2 (Siglec-2); CD antigen CD22.
Gene name:  CD22
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 59 5
GENE REF ISO

Function

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Overview 
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+933  
Cell adhesion molecules (CAMs)  hsa04514+933  
Hematopoietic cell lineage  hsa04640+933  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD22
GenomeRNAi: 933
PRO: PR:P20273