ALOX5AP - Arachidonate 5-lipoxygenase-activating protein - human protein (Function)
 
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ALOX5AP »  Arachidonate 5-lipoxygenase-activating protein
 
Protein also known as:  MK-886-binding protein.
Gene name:  ALOX5AP
Family name: MAPEG
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.  
2
  • CuratedUniProtKB
GO molecular function 
Arachidonic acid bindingdefinition[GO:0050544]  
1
  • IDAUniProtKB
Enzyme activator activitydefinition[GO:0008047] silver  
  • IEAInterPro 2 GO
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Not  Glutathione peroxidase activitydefinition[GO:0004602] silver  
  • IBARefGenome
Not  Glutathione transferase activitydefinition[GO:0004364] silver  
  • IBARefGenome
Not  Leukotriene-C4 synthase activitydefinition[GO:0004464] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • IPIUniProtKB
GO biological process 
Cellular response to calcium iondefinition[GO:0071277]  
1
  • IDAUniProtKB
Leukotriene biosynthetic processdefinition[GO:0019370]  
1
  • IDAUniProtKB
Leukotriene production involved in inflammatory responsedefinition[GO:0002540] silver  
  • IEAOrtholog Compara
Positive regulation of acute inflammatory responsedefinition[GO:0002675] silver  
  • IEAOrtholog Compara
Positive regulation of catalytic activitydefinition[GO:0043085]  
  • IEAInterPro 2 GO
Protein homotrimerizationdefinition[GO:0070207]  
1
  • IPIUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Synthesis of 5-eicosatetraenoic acids  REACT_150209  
Synthesis of Leukotrienes (LT) and Eoxins (EX)  REACT_150420  
Synthesis of Lipoxins (LX)  REACT_150320  
 
More information is available from:
 

Keywords

Biological process 
Leukotriene biosynthesis  definition   [KW-0434]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links