TNFRSF1B - Tumor necrosis factor receptor superfamily member 1B - human protein (Function)
 
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TNFRSF1B »  Tumor necrosis factor receptor superfamily member 1B
 
Protein also known as:  Tumor necrosis factor receptor type II (TNFR-II); CD antigen CD120b; International Nonproprietary Name Etanercept. Cleaved into:  Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2.
Gene name:  TNFRSF1B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 184 2
GENE REF ISO

Function

 show evidences
Overview 
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha.  
2
  • CuratedUniProtKB
Isoform  Iso 2   Blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Tumor necrosis factor-activated receptor activitydefinition[GO:0005031] silver  
  • IEAOrtholog Compara
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
  • IEAOrtholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • IMPBHF-UCL
Immune responsedefinition[GO:0006955] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Positive regulation of membrane protein ectodomain proteolysisdefinition[GO:0051044]  
1
  • IMPBHF-UCL
RNA destabilizationdefinition[GO:0050779] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+7133  
Amyotrophic lateral sclerosis (ALS)  hsa05014+7133  
Cytokine-cytokine receptor interaction  hsa04060+7133  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TNFRSF1B
GenomeRNAi: 7133
PRO: PR:P20333
Chemistry
GuidetoPHARMACOLOGY: 1871