TNFRSF1B - Tumor necrosis factor receptor superfamily member 1B - human protein (Medical)
 
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TNFRSF1B »  Tumor necrosis factor receptor superfamily member 1B
 
Protein also known as:  Tumor necrosis factor receptor type II (TNF-RII); CD antigen CD120b; International Nonproprietary Name Etanercept. Cleaved into:  Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2.
Gene name:  TNFRSF1B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 184 2
GENE REF ISO

Displayed isoform: Iso 1     

 
 

Medical

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Pharmaceutical 
Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors.  
  • CuratedUniProtKB
According to DrugBank, this protein binds/interacts with the following drugs:
Etanercept  DB00005  
Infliximab  DB00065  
 

Keywords

Technical term 
Pharmaceutical  definition   [KW-0582]
Reference proteome  definition   [KW-1185]
 

Further external links

Organism-specific databases
CTD: 7133
PharmGKB: PA36610
Polymorphism databases
DMDM: 21264534
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.