TAC1 - Protachykinin-1 - human protein (Function)
 
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TAC1 »  Protachykinin-1
 
Cleaved into:  Neurokinin A; Neuropeptide K; Substance P.
Gene name:  TAC1
Family name: Tachykinin
Entry whose protein(s) existence is based on evidence at protein level
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1 133 4
GENE REF ISO

Function

 show evidences
Overview 
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Substance P receptor bindingdefinition[GO:0031835] silver  
  • IEAOrtholog Compara
GO biological process 
Associative learningdefinition[GO:0008306] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Detection of abiotic stimulusdefinition[GO:0009582]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Inseminationdefinition[GO:0007320]  
1
  • TASPINC
Long-term memorydefinition[GO:0007616] silver  
  • IEAOrtholog Compara
Negative regulation of heart ratedefinition[GO:0010459] silver  
  • IEAOrtholog Compara
Neuropeptide signaling pathwaydefinition[GO:0007218]  
  • IEAUniProtKB KW
Positive regulation of action potentialdefinition[GO:0045760] silver  
  • IEAOrtholog Compara
Positive regulation of acute inflammatory responsedefinition[GO:0002675] silver  
  • IEAOrtholog Compara
Positive regulation of corticosterone secretiondefinition[GO:2000854] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDAUniProtKB
Positive regulation of epithelial cell migrationdefinition[GO:0010634] silver  
  • IEAOrtholog Compara
Positive regulation of lymphocyte proliferationdefinition[GO:0050671] silver  
  • IEAOrtholog Compara
Positive regulation of ossificationdefinition[GO:0045778] silver  
  • IEAOrtholog Compara
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
  • IEAOrtholog Compara
Positive regulation of saliva secretiondefinition[GO:0046878] silver  
  • IEAOrtholog Compara
Positive regulation of stress fiber assemblydefinition[GO:0051496] silver  
  • IEAOrtholog Compara
Positive regulation of synaptic transmission, cholinergicdefinition[GO:0032224] silver  
  • IEAOrtholog Compara
Positive regulation of synaptic transmission, GABAergicdefinition[GO:0032230] silver  
  • IEAOrtholog Compara
Regulation of blood pressuredefinition[GO:0008217] silver  
  • IEAOrtholog Compara
Response to hormonedefinition[GO:0009725] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to morphinedefinition[GO:0043278] silver  
  • IEAOrtholog Compara
Response to paindefinition[GO:0048265] silver  
  • IEAOrtholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268]  
  • IEAUniProtKB KW
Tachykinin receptor signaling pathwaydefinition[GO:0007217] silver  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Tachykinin receptors bind tachykinins  REACT_16963  
 

Keywords

Molecular function 
Neuropeptide  definition   [KW-0527]
Neurotransmitter  definition   [KW-0529]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TAC1
GenomeRNAi: 6863
PRO: PR:P20366