NPR2 - Atrial natriuretic peptide receptor 2 - human protein (Function)
 
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NPR2 »  Atrial natriuretic peptide receptor 2   [ EC 4.6.1.2 ]
 
Protein also known as:  Atrial natriuretic peptide receptor type B (NPR-B).
Gene name:  NPR2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 36 2
GENE REF ISO

Function

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Overview 
Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
GTP bindingdefinition[GO:0005525] silver  
  • IEAOrtholog Compara
Guanylate cyclase activitydefinition[GO:0004383]  
1
  • IDAUniProtKB
Hormone bindingdefinition[GO:0042562]  
2
  • IPIUniProtKB
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Natriuretic peptide receptor activitydefinition[GO:0016941]  
2
  • IDAUniProtKB
Peptide hormone bindingdefinition[GO:0017046] silver  
  • IEAOrtholog Compara
Protein kinase activitydefinition[GO:0004672] silver  
  • IEAInterPro 2 GO
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
GO biological process 
Bone developmentdefinition[GO:0060348] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Cellular response to granulocyte macrophage colony-stimulating factor stimulusdefinition[GO:0097011]  
1
  • IEPUniProtKB
cGMP biosynthetic processdefinition[GO:0006182]  
1
  • IDAUniProtKB
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Ossificationdefinition[GO:0001503]  
  • IEAUniProtKB KW
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Receptor guanylyl cyclase signaling pathwaydefinition[GO:0007168]  
1
  • IDAUniProtKB
Regulation of blood pressuredefinition[GO:0008217]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.2: GTP 3',5'-cyclic GMP + diphosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Purine metabolism  hsa00230+4882  
Vascular smooth muscle contraction  hsa04270+4882  
 

Keywords

Biological process 
Osteogenesis  definition   [KW-0892]
cGMP biosynthesis  definition   [KW-0141]
Molecular function 
Lyase  definition   [KW-0456]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: NPR2
GenomeRNAi: 4882
PRO: PR:P20594
Chemistry
GuidetoPHARMACOLOGY: 1748