ATP4A - Potassium-transporting ATPase alpha chain 1 - human protein (Function)
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ATP4A »  Potassium-transporting ATPase alpha chain 1   [ EC ]
Protein also known as:  Gastric H(+)/K(+) ATPase subunit alpha.
Gene name:  ATP4A
Entry whose protein(s) existence is based on evidence at protein level
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Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.1.2  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Hydrogen:potassium-exchanging ATPase activitydefinition[GO:0008900]  
  • IEAEC 2 GO
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
GO biological process 
ATP biosynthetic processdefinition[GO:0006754] silver  
  • IEAInterPro 2 GO
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
pH reductiondefinition[GO:0045851] silver  
  • IEAOrtholog Compara
Regulation of proton transportdefinition[GO:0010155] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + H(2)O + H(+)(In) + K(+)(Out) ADP + phosphate + H(+)(Out) + K(+)(In).  
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+495  
Gastric acid secretion  hsa04971+495  
Oxidative phosphorylation  hsa00190+495  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
More information is available from:


Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 495
PRO: PR:P20648