GZMH - Granzyme H - human protein (Function)
 
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GZMH »  Granzyme H   [ EC 3.4.21.- ]
 
Protein also known as:  Cytotoxic T-lymphocyte proteinase.
Gene name:  GZMH
Family name: Peptidase S1 » Granzyme
Entry whose protein(s) existence is based on evidence at protein level
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1 24 3
GENE REF ISO

Function

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Overview 
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.  
2
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • NASUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
2
  • NASUniProtKB
Cytolysisdefinition[GO:0019835]  
  • IEAUniProtKB KW
Proteolysisdefinition[GO:0006508] silver  
  • IBARefGenome
Enzymatic activity 
It is regulated in the following manner
Inhibited by SERPINB1.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Cytolysis  definition   [KW-0204]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GZMH
GenomeRNAi: 2999
PRO: PR:P20718