BCL3 - B-cell lymphoma 3 protein - human protein (Function)
 
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BCL3 »  B-cell lymphoma 3 protein  (BCL-3)
 
Protein also known as:  Proto-oncogene BCL3.
Gene name:  BCL3
Entry whose protein(s) existence is based on evidence at protein level
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1 71 1
GENE REF ISO

Function

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Overview 
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Protein binding, bridgingdefinition[GO:0030674]  
1
  • TASUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Transcription factor bindingdefinition[GO:0008134]  
4
  • IPIUniProtKB
GO biological process 
Antimicrobial humoral responsedefinition[GO:0019730] silver  
  • IEAOrtholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAUniProtKB
Defense response to bacteriumdefinition[GO:0042742] silver  
  • IEAOrtholog Compara
Defense response to protozoandefinition[GO:0042832] silver  
  • IEAOrtholog Compara
DNA damage response, signal transduction by p53 class mediatordefinition[GO:0030330]  
1
  • IMPUniProtKB
Extracellular matrix organizationdefinition[GO:0030198] silver  
  • IEAOrtholog Compara
Follicular dendritic cell differentiationdefinition[GO:0002268] silver  
  • IEAOrtholog Compara
Germinal center formationdefinition[GO:0002467] silver  
  • IEAOrtholog Compara
Humoral immune response mediated by circulating immunoglobulindefinition[GO:0002455] silver  
  • IEAOrtholog Compara
I-kappaB kinase/NF-kappaB signalingdefinition[GO:0007249]  
1
  • IDAUniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771]  
1
  • IMPMGI
Maintenance of protein location in nucleusdefinition[GO:0051457]  
1
  • NASUniProtKB
Marginal zone B cell differentiationdefinition[GO:0002315] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of interleukin-8 biosynthetic processdefinition[GO:0045415]  
1
  • IMPUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Negative regulation of tumor necrosis factor biosynthetic processdefinition[GO:0042536] silver  
  • IEAOrtholog Compara
Positive regulation of interferon-gamma productiondefinition[GO:0032729] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-10 biosynthetic processdefinition[GO:0045082] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Positive regulation of translationdefinition[GO:0045727]  
1
  • IMPUniProtKB
Protein import into nucleus, translocationdefinition[GO:0000060]  
1
  • IMPUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • IDAUniProtKB
Regulation of DNA bindingdefinition[GO:0051101]  
1
  • IEPUniProtKB
Regulation of NF-kappaB import into nucleusdefinition[GO:0042345]  
1
  • IEPUniProtKB
Response to UV-Cdefinition[GO:0010225]  
1
  • IDAUniProtKB
Response to virusdefinition[GO:0009615]  
1
  • IDAUniProtKB
Spleen developmentdefinition[GO:0048536] silver  
  • IEAOrtholog Compara
T-helper 1 type immune responsedefinition[GO:0042088] silver  
  • IEAOrtholog Compara
T-helper 2 cell differentiationdefinition[GO:0045064] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • IDAUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCL3
GenomeRNAi: 602
PRO: PR:P20749