NTF3 - Neurotrophin-3 - human protein (Function)
 
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NTF3 »  Neurotrophin-3  (NT-3)
 
Protein also known as:  Nerve growth factor 2 (NGF-2).
Gene name:  NTF3
Family name: NGF-beta
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 82 2
GENE REF ISO

Function

 show evidences
Overview 
Seems to promote the survival of visceral and proprioceptive sensory neurons.  
  • CuratedUniProtKB
GO molecular function 
Chemoattractant activitydefinition[GO:0042056]  
1
  • IDABHF-UCL
Growth factor activitydefinition[GO:0008083]  
1
  • IDABHF-UCL
Nerve growth factor bindingdefinition[GO:0048406] silver  
  • IEAOrtholog Compara
Neurotrophin receptor bindingdefinition[GO:0005165] silver  
  • IEAInterPro 2 GO
Receptor bindingdefinition[GO:0005102]  
1
  • TASPINC
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • IDABHF-UCL
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • IDABHF-UCL
Activation of Ras GTPase activitydefinition[GO:0032856]  
1
  • IDABHF-UCL
Axon guidancedefinition[GO:0007411] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Enteric nervous system developmentdefinition[GO:0048484] silver  
  • IEAOrtholog Compara
Epidermis developmentdefinition[GO:0008544] silver  
  • IEAOrtholog Compara
Glial cell fate determinationdefinition[GO:0007403] silver  
  • IEAOrtholog Compara
Induction of positive chemotaxisdefinition[GO:0050930]  
1
  • IDABHF-UCL
Mechanoreceptor differentiationdefinition[GO:0042490] silver  
  • IEAOrtholog Compara
Myelinationdefinition[GO:0042552] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050732]  
1
  • IDABHF-UCL
Nerve developmentdefinition[GO:0021675] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Neuromuscular synaptic transmissiondefinition[GO:0007274] silver  
  • IEAOrtholog Compara
Peripheral nervous system developmentdefinition[GO:0007422] silver  
  • IEAOrtholog Compara
Positive chemotaxisdefinition[GO:0050918]  
1
  • IDAGOC
Positive regulation of actin cytoskeleton reorganizationdefinition[GO:2000251]  
1
  • IDABHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDABHF-UCL
Positive regulation of glial cell differentiationdefinition[GO:0045687] silver  
  • IEAOrtholog Compara
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • IDABHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDABHF-UCL
Positive regulation of receptor internalizationdefinition[GO:0002092]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of synaptic transmissiondefinition[GO:0050804] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Smooth muscle cell differentiationdefinition[GO:0051145] silver  
  • IEAOrtholog Compara
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+4908  
Neurotrophin signaling pathway  hsa04722+4908  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Neurotrophin-3
GenomeRNAi: 4908
PRO: PR:P20783