MAK - Serine/threonine-protein kinase MAK - human protein (Function)
 
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MAK »  Serine/threonine-protein kinase MAK   [ EC 2.7.11.22 ]
 
Protein also known as:  Male germ cell-associated kinase.
Gene name:  MAK
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • NASUniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • IDAUniProtKB
GO biological process 
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Multicellular organismal developmentdefinition[GO:0007275]  
  • IEAUniProtKB KW
Photoreceptor cell maintenancedefinition[GO:0045494]  
  • ISSOrtholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Spermatogenesisdefinition[GO:0007283]  
1
  • NASUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAK_(gene)
GenomeRNAi: 4117
PRO: PR:P20794
Chemistry
GuidetoPHARMACOLOGY: 2061