CAPN3 - Calpain-3 - human protein (Function)
 
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CAPN3 »  Calpain-3   [ EC 3.4.22.54 ]
 
Protein also known as:  Muscle-specific calcium-activated neutral protease 3.
Gene name:  CAPN3
Family name: Peptidase C2
Entry whose protein(s) existence is based on evidence at protein level
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1 39 5
GENE REF ISO

Function

 show evidences
Overview 
Calcium-regulated non-lysosomal thiol-protease.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
  • ISSOrtholog Curator
Calcium-dependent cysteine-type endopeptidase activitydefinition[GO:0004198]  
1
  • TASUniProtKB
  • IBARefGenome
  • ISSOrtholog Curator
Catalytic activitydefinition[GO:0003824]  
1
  • IDAUniProtKB
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • TASPINC
Ligase regulator activitydefinition[GO:0055103]  
1
  • IDAUniProtKB
Peptidase activitydefinition[GO:0008233]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein complex scaffolddefinition[GO:0032947]  
  • ISSOrtholog Curator
Signal transducer activitydefinition[GO:0004871]  
1
  • TASPINC
Sodium ion bindingdefinition[GO:0031402]  
  • ISSOrtholog Curator
Structural constituent of muscledefinition[GO:0008307]  
  • ISSOrtholog Curator
Titin bindingdefinition[GO:0031432]  
2
  • IPIUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Autolysisdefinition[GO:0001896] silver  
  • IEAOrtholog Compara
Cellular response to calcium iondefinition[GO:0071277]  
  • ISSOrtholog Curator
Cellular response to salt stressdefinition[GO:0071472]  
  • ISSOrtholog Curator
G1 to G0 transition involved in cell differentiationdefinition[GO:0070315] silver  
  • IEAOrtholog Compara
Muscle cell cellular homeostasisdefinition[GO:0046716]  
1
  • TASUniProtKB
Muscle organ developmentdefinition[GO:0007517]  
1
  • TASUniProtKB
Muscle structure developmentdefinition[GO:0061061]  
  • ISSOrtholog Curator
Myofibril assemblydefinition[GO:0030239]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of protein sumoylationdefinition[GO:0033234]  
1
  • IDAUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPUniProtKB
Positive regulation of proteolysisdefinition[GO:0045862]  
  • ISSOrtholog Curator
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281]  
  • ISSOrtholog Curator
Positive regulation of satellite cell activation involved in skeletal muscle regenerationdefinition[GO:0014718]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IMPUniProtKB
Protein complex assemblydefinition[GO:0006461]  
  • ISSOrtholog Curator
Protein localization to membranedefinition[GO:0072657]  
  • ISSOrtholog Curator
Proteolysisdefinition[GO:0006508]  
4
  • IDAUniProtKB
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • IDAUniProtKB
Regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043122]  
1
  • IMPUniProtKB
Regulation of myoblast differentiationdefinition[GO:0045661] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592]  
  • ISSOrtholog Curator
Response to muscle activitydefinition[GO:0014850]  
  • ISSOrtholog Curator
Sarcomere organizationdefinition[GO:0045214]  
  • ISSOrtholog Curator
Self proteolysisdefinition[GO:0097264]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASGOC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.54: Broad endopeptidase activity.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by micromolar concentrations of calcium and inhibited by calpastatin.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CAPN3
GenomeRNAi: 825
PRO: PR:P20807