AGA - N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase - human protein (Function)
 
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Protein
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AGA »  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase   [ EC 3.5.1.26 ]
 
Protein also known as:  N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase. Cleaved into:  Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain.
Gene name:  AGA
Family name: Ntn-hydrolase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.  
  • CuratedUniProtKB
GO molecular function 
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activitydefinition[GO:0003948]  
2
  • IDAUniProtKB
Peptidase activitydefinition[GO:0008233]  
  • IEAUniProtKB KW
Protein self-associationdefinition[GO:0043621] silver  
  • IEAOrtholog Compara
GO biological process 
Protein deglycosylationdefinition[GO:0006517]  
2
  • IDAUniProtKB
Protein maturationdefinition[GO:0051604] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.1.26: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O N-acetyl-beta-D-glucosaminylamine + L-aspartate.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+175  
Other glycan degradation  hsa00511+175  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P20933
Other
GeneWiki: Aspartylglucosaminidase
GenomeRNAi: 175
PRO: PR:P20933