RASA1 - Ras GTPase-activating protein 1 - human protein (Function)
 
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RASA1 »  Ras GTPase-activating protein 1  (GAP)
 
Protein also known as:  Ras p21 protein activator.
Gene name:  RASA1
Entry whose protein(s) existence is based on evidence at protein level
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1 93 2
GENE REF ISO

Function

 show evidences
Overview 
Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.  
2
  • CuratedUniProtKB
GO molecular function 
Glycoprotein bindingdefinition[GO:0001948]  
1
  • IPIUniProtKB
GTPase bindingdefinition[GO:0051020]  
1
  • IPIUniProtKB
Potassium channel inhibitor activitydefinition[GO:0019870]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
14
  • IPIIntAct
  • IPIUniProtKB
Ras GTPase activator activitydefinition[GO:0005099] silver  
  • IBARefGenome
Receptor bindingdefinition[GO:0005102]  
2
  • IPIUniProtKB
GO biological process 
Embryo developmentdefinition[GO:0009790]  
  • ISSOrtholog Curator
Intracellular signal transductiondefinition[GO:0035556]  
1
  • NASUniProtKB
Mitotic cytokinesisdefinition[GO:0000281]  
  • ISSOrtholog Curator
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • IDAUniProtKB
Negative regulation of cell-matrix adhesiondefinition[GO:0001953]  
1
  • IDAUniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
  • ISSOrtholog Curator
Negative regulation of Ras protein signal transductiondefinition[GO:0046580] silver  
  • IBARefGenome
Positive regulation of Ras GTPase activitydefinition[GO:0032320] silver  
  • IBARefGenome
Regulation of actin filament polymerizationdefinition[GO:0030833]  
1
  • IDAUniProtKB
Regulation of cell shapedefinition[GO:0008360]  
1
  • NASUniProtKB
Regulation of RNA metabolic processdefinition[GO:0051252]  
1
  • NASUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • IDAUniProtKB
Vasculogenesisdefinition[GO:0001570]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+5921  
MAPK signaling pathway  hsa04010+5921  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links