FUT3 - Galactoside 3(4)-L-fucosyltransferase - human protein (Function)
 
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FUT3 »  Galactoside 3(4)-L-fucosyltransferase   [ EC 2.4.1.65 ]
 
Protein also known as:  Blood group Lewis alpha-4-fucosyltransferase (Lewis FT).
Gene name:  FUT3
Family name: Glycosyltransferase 10
Entry whose protein(s) existence is based on evidence at protein level
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1 51 1
GENE REF ISO

Function

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Overview 
May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.  
  • CuratedUniProtKB
GO molecular function 
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activitydefinition[GO:0017060]  
  • IEAEC 2 GO
Alpha-(1->3)-fucosyltransferase activitydefinition[GO:0046920]  
1
  • IDABHF-UCL
Fucosyltransferase activitydefinition[GO:0008417]  
1
  • IDABHF-UCL
GO biological process 
Cell-cell recognitiondefinition[GO:0009988]  
1
  • ICBHF-UCL
Fucosylationdefinition[GO:0036065]  
2
  • IDAGOC
  • IEAInterPro 2 GO
  • IEAEC 2 GO
Macromolecule glycosylationdefinition[GO:0043413]  
2
  • IDABHF-UCL
Oligosaccharide biosynthetic processdefinition[GO:0009312]  
1
  • IDABHF-UCL
Protein glycosylationdefinition[GO:0006486]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.65: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 10  GT10  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosphingolipid biosynthesis - lacto and neolacto series  hsa00601+2525  
Metabolic pathways  hsa01100+2525  
 

Keywords

Molecular function 
Blood group antigen  definition   [KW-0095]
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Fucosyltransferase_3
GenomeRNAi: 2525
PRO: PR:P21217