PTN - Pleiotrophin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
PTN »  Pleiotrophin  (PTN)
 
Protein also known as:  Heparin-binding neurite outgrowth-promoting factor 1 (HBNF-1).
Gene name:  PTN
Family name: Pleiotrophin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 110 1
GENE REF ISO

Function

 show evidences
Overview 
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.  
3
  • UniProtKB
GO molecular function 
Chondroitin sulfate proteoglycan bindingdefinition[GO:0035373] silver  
1
  • Ortholog Compara
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Heparin bindingdefinition[GO:0008201] silver  
1
  • Ortholog Compara
Protein phosphatase inhibitor activitydefinition[GO:0004864]  
1
  • PINC
GO biological process 
Bone mineralizationdefinition[GO:0030282] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
Cellular response to platelet-derived growth factor stimulusdefinition[GO:0036120] silver  
1
  • Ortholog Compara
Cellular response to vitamin Ddefinition[GO:0071305] silver  
1
  • Ortholog Compara
Hindbrain developmentdefinition[GO:0030902] silver  
1
  • Ortholog Compara
Learningdefinition[GO:0007612] silver  
1
  • Ortholog Compara
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • GOC
Negative regulation of membrane potentialdefinition[GO:0045837] silver  
1
  • Ortholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Positive regulation of cell divisiondefinition[GO:0051781]  
1
  • UniProtKB KW
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • PINC
Positive regulation of cell-substrate adhesiondefinition[GO:0010811] silver  
1
  • Ortholog Compara
Positive regulation of hepatocyte proliferationdefinition[GO:2000347] silver  
1
  • Ortholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
1
  • Ortholog Compara
Response to activitydefinition[GO:0014823] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to nerve growth factordefinition[GO:1990089] silver  
1
  • Ortholog Compara
Retinal rod cell differentiationdefinition[GO:0060221] silver  
1
  • Ortholog Compara
Skeletal muscle acetylcholine-gated channel clusteringdefinition[GO:0071340] silver  
1
  • Ortholog Compara
Spinal cord developmentdefinition[GO:0021510] silver  
1
  • Ortholog Compara
Transmembrane receptor protein tyrosine phosphatase signaling pathwaydefinition[GO:0007185]  
1
  • PINC
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Pleiotrophin
GenomeRNAi: 5764
PRO: PR:P21246