PTN - Pleiotrophin - human protein (Function)
 
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Protein
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References

 
PTN »  Pleiotrophin  (PTN)
 
Protein also known as:  Heparin-binding neurite outgrowth-promoting factor 1 (HBNF-1).
Gene name:  PTN
Family name: Pleiotrophin
Entry whose protein(s) existence is based on evidence at protein level
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1 101 1
GENE REF ISO

Function

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Overview 
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.  
2
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
Protein phosphatase inhibitor activitydefinition[GO:0004864]  
1
  • TASPINC
GO biological process 
Bone mineralizationdefinition[GO:0030282] silver  
  • IEAOrtholog Compara
Learningdefinition[GO:0007612] silver  
  • IEAOrtholog Compara
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • TASGOC
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Transmembrane receptor protein tyrosine phosphatase signaling pathwaydefinition[GO:0007185]  
1
  • TASPINC
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Pleiotrophin
GenomeRNAi: 5764
PRO: PR:P21246