ATP6V1B2 - V-type proton ATPase subunit B, brain isoform - human protein (Function)
 
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ATP6V1B2 »  V-type proton ATPase subunit B, brain isoform  (V-ATPase subunit B 2)
 
Protein also known as:  Endomembrane proton pump 58 kDa subunit.
Gene name:  ATP6V1B2
Entry whose protein(s) existence is based on evidence at protein level
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1 25 1
GENE REF ISO

Function

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Overview 
Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily  3.A.2.2.4  
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAInterPro 2 GO
Hydrogen ion transmembrane transporter activitydefinition[GO:0015078]  
1
  • TASPINC
Proton-transporting ATPase activity, rotational mechanismdefinition[GO:0046961]  
1
  • TASPINC
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • TASGOC
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
Proton transportdefinition[GO:0015992]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+526  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+526  
Metabolic pathways  hsa01100+526  
Oxidative phosphorylation  hsa00190+526  
Phagosome  hsa04145+526  
Rheumatoid arthritis  hsa05323+526  
Synaptic vesicle cycle  hsa04721+526  
Vibrio cholerae infection  hsa05110+526  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP6V1B2
GenomeRNAi: 526
PRO: PR:P21281