ATP6V1C1 - V-type proton ATPase subunit C 1 - human protein (Function)
 
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ATP6V1C1 »  V-type proton ATPase subunit C 1  (V-ATPase subunit C 1)
 
Protein also known as:  Vacuolar proton pump subunit C 1.
Gene name:  ATP6V1C1
Family name: V-ATPase C subunit
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 17 1
GENE REF ISO

Function

 show evidences
Overview 
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily  3.A.2.2.4  
GO molecular function 
Hydrogen-exporting ATPase activity, phosphorylative mechanismdefinition[GO:0008553] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Proton-transporting ATPase activity, rotational mechanismdefinition[GO:0046961]  
1
  • TASPINC
Transporter activitydefinition[GO:0005215]  
1
  • NASPINC
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • TASGOC
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
Metabolic processdefinition[GO:0008152]  
1
  • TASGOC
Proton transportdefinition[GO:0015992]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+528  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+528  
Metabolic pathways  hsa01100+528  
Oxidative phosphorylation  hsa00190+528  
Phagosome  hsa04145+528  
Rheumatoid arthritis  hsa05323+528  
Synaptic vesicle cycle  hsa04721+528  
Vibrio cholerae infection  hsa05110+528  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP6V1C1
GenomeRNAi: 528
PRO: PR:P21283