FLNA - Filamin-A - human protein (Function)
 
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FLNA »  Filamin-A  (FLN-A)
 
Protein also known as:  Endothelial actin-binding protein.
Gene name:  FLNA
Family name: Filamin
Entry whose protein(s) existence is based on evidence at protein level
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1 321 2
GENE REF ISO

Function

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Overview 
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.  
1
  • CuratedUniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015]  
3
  • IDABHF-UCL
Fc-gamma receptor I complex bindingdefinition[GO:0034988]  
1
  • IDABHF-UCL
Glycoprotein bindingdefinition[GO:0001948]  
2
  • IDABHF-UCL
Mu-type opioid receptor bindingdefinition[GO:0031852] silver  
  • IEAOrtholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
20
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
Protein kinase C bindingdefinition[GO:0005080] silver  
  • IEAOrtholog Compara
Rac GTPase bindingdefinition[GO:0048365]  
1
  • IDABHF-UCL
Ral GTPase bindingdefinition[GO:0017160]  
1
  • IDABHF-UCL
Rho GTPase bindingdefinition[GO:0017048]  
1
  • IDABHF-UCL
Signal transducer activitydefinition[GO:0004871]  
1
  • IMPUniProtKB
SMAD bindingdefinition[GO:0046332] silver  
  • IEAOrtholog Compara
Small GTPase bindingdefinition[GO:0031267]  
1
  • IDABHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
GO biological process 
Actin crosslink formationdefinition[GO:0051764]  
1
  • IDABHF-UCL
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • IDABHF-UCL
Adenylate cyclase-inhibiting dopamine receptor signaling pathwaydefinition[GO:0007195]  
1
  • IMPBHF-UCL
Cilium assemblydefinition[GO:0042384]  
1
  • IMPUniProtKB
Cytoplasmic sequestering of proteindefinition[GO:0051220]  
1
  • IMPBHF-UCL
Early endosome to late endosome transportdefinition[GO:0045022] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837] silver  
  • IEAOrtholog Compara
Establishment of protein localizationdefinition[GO:0045184]  
1
  • IDABHF-UCL
mRNA transcription from RNA polymerase II promoterdefinition[GO:0042789] silver  
  • IEAOrtholog Compara
Negative regulation of protein catabolic processdefinition[GO:0042177]  
1
  • IMPBHF-UCL
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • IDAUniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IMPUniProtKB
Positive regulation of transcription factor import into nucleusdefinition[GO:0042993]  
1
  • IMPUniProtKB
Protein localization to cell surfacedefinition[GO:0034394]  
1
  • IDABHF-UCL
Protein stabilizationdefinition[GO:0050821]  
1
  • IMPBHF-UCL
Receptor clusteringdefinition[GO:0043113]  
1
  • IDABHF-UCL
Spindle assembly involved in mitosisdefinition[GO:0090307]  
1
  • IDAMGI
Pathways 
According to KEGG, this protein belongs to the following pathways:
Focal adhesion  hsa04510+2316  
MAPK signaling pathway  hsa04010+2316  
Salmonella infection  hsa05132+2316  
According to Reactome, this protein belongs to the following pathways:
Cell-extracellular matrix interactions  REACT_20649  
GP1b-IX-V activation signalling  REACT_23847  
Caution 
Variant Thr-1764 has been originally associated with periventricular nodular heterotopia (PubMed12612583). It has been subsequently reported as a benign polymorphism (PubMed12612583).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FLNA
GenomeRNAi: 2316
PRO: PR:P21333